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20 Rs Aveolar Ventilation

20 Rs Aveolar Ventilation - ALVEOLAR GAS EXCHANGE Page 1...

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ALVEOLAR GAS EXCHANGE AC Brown Page 1 A7c ALVEOLAR-CAPILLARY EXCHANGE A. Mechanism 1. Simple diffusion through tissue and fluids B. Characteristics of Alveolar-Capillary Diffusion 1. Driving force: partial pressure difference between alveoli and pulmonary capillary blood for each gas 2. Rate of diffusion: Product of driving force and ease of diffusion 3. Gases diffuse independently, according to each gas’s partial pressure difference and ease of diffusion 4. Ease of diffusion depends on a. Area: the alveolar area available for diffusion (i.e., in contact with pulmonary capillary blood) is very large (order of 70 m 2 ) Note effect of degenerative lung disease Note effect of pulmonary embolism b. Distance: even though gas must pass through several compartments, all are normally thin (even interstitial space), so total diffusion distance is small Note effect of pulmonary edema
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ALVEOLAR GAS EXCHANGE AC Brown Page 2 A7c ALVEOLAR-CAPILLARY EXCHANGE (continued) B. 4. Ease of diffusion (continued) c. Diffusion Coefficient:
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