21 Rs Blood gas transport

21 Rs Blood gas transport - BLOOD GAS TRANSPORT Page 1...

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BLOOD GAS TRANSPORT AC Brown Page 1 A6k OXYGEN TRANSPORT IN BLOOD A. Dissolved O 2 (physical solution) 1. amount directly proportional to P O2 (oxygen partial pressure) 2. not generally insignificant at normal P O2 since O2 is not very soluble 3. can become significant in hyperbaric conditions (very high P O2 ) B. Bound to Hemoglobin (Hb) 1. Reaction Hb = Reduced hemoglobin (deoxygenated, blue or cyan) HbO 2 = Oxygenated hemoglobin, oxyhemoglobin (red) Note: Cyanosis (bluish color of skin or mucosa) occurs when blood concentration of reduced Hb > 60-80 gm/l (6-8 gm/dl) Note affinity of Hb for carbon monoxide (200x O 2 affinity) 2. Binding Capacity 1 gm of normal Hb can bind a maximum of 1.34 ml O 2 (100% saturation) 3. Shape of Hb-O 2 dissociation (or saturation) curve Expressed as % of Hb maximum capacity as a function of P O2
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BLOOD GAS TRANSPORT AC Brown Page 2 A6k OXYGEN TRANSPORT (continued) Note points P O2 = 40 mmHg Saturation = 75% P O2 = 100 mmHg Saturation = 97.5% Note that blood is almost completely saturated at normal alveolar P O2 4. Changes in shape ("shifts" of Hb-O2 dissociation curve) Curve not constant but can shift with changes in physiological
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21 Rs Blood gas transport - BLOOD GAS TRANSPORT Page 1...

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