27 Endo Pancreas

27 Endo Pancreas - ENDOCRINE PANCREAS page 1 INTRODUCTION...

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ENDOCRINE PANCREAS AC Brown page 1 A6k-a INTRODUCTION A. Functional Anatomy B. Secretions 1. Acinar cells: exocrine functions – secrete digestive enzymes and electrolytes (especially bicarbonate) into the small intestine 2. Islet of Langerhan's cells: endocrine secretion a. A (alpha) cells: Glucagon b. B (beta) cells : Insulin c. also D cells (secrete somatostatin) and F cells (secrete pancreatic polypeptide) INSULIN A. Synthesis and Distribution 1. Protein 2. Discharged into the blood, probably not protein bound 3. Rapid turnover, about 10 minutes B. Actions – occur when insulin binds to cell insulin receptors 1. Increase glucose entry into most cells by either facilitated diffusion or secondary active transport with Na ion Note 1: insulin is not necessary for glucose uptake by nervous tissue Note 2: glucose is the only metabolic substrate that is readily utilizable by brain neurons; in the absence of glucose, neuron activity is depressed (e.g. acute hypoglycemia => coma)
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ENDOCRINE PANCREAS AC Brown
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This note was uploaded on 01/03/2012 for the course BIO 308 taught by Professor Acbrown during the Spring '10 term at Portland.

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27 Endo Pancreas - ENDOCRINE PANCREAS page 1 INTRODUCTION...

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