28 Endo Thyroid

28 Endo Thyroid - THYROID GLAND page 1 INTRODUCTION A....

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THYROID GLAND AC Brown page 1 A6k-a INTRODUCTION A. Functional Anatomy 1. "Shield" shaped gland lying over the trachea in the neck 2. Average weight = 20 gm 3. Rich blood supply for its size, 50-100 ml/min 4. Contains 25% of total body iodine Note: High blood flow required to extract sufficient iodine from the blood B. Hormones 1. "Energy" hormones a. Thyroxine, tetraiodothyronine, T4 b. triiodothhyronine, T3 2. Calcium metabolism hormone: Calcitonin, thyrocalcitonin HORMONE (T4 & T3) SYNTHESIS AND RELEASE A. Gland Functional Unit: Thyroid Follicle
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THYROID GLAND AC Brown page 2 A6k-a HORMONE (T4 & T3) SYNTHESIS AND RELEASE (continued) B. Synthesis and Storage 1. Active transport of iodide ion from the interstitial fluid into the cells (the iodide ion taken from the interstitial fluid is replaced from the circulation 2. Diffusion of iodide ion into the colloid center of the follicle 3. Conversion of iodide ion to iodine molecule 4. Binding iodine to globulin-bound thyronine; T4 is formed by
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This note was uploaded on 01/03/2012 for the course BIO 308 taught by Professor Acbrown during the Spring '10 term at Portland.

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28 Endo Thyroid - THYROID GLAND page 1 INTRODUCTION A....

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