chapter6b Communication, Integration,and Homeostasis 2

chapter6b Communication, Integration,and Homeostasis 2 -...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Chapter 6b Communication, Integration, and Homeostasis Figure 6-15 Novel Signal Molecules: Calcium Calcium as an intracellular messenger Extracellular fluid Intracellular fluid Electrical signal released from intracellular Ca2+ stores Ca2+ binds to proteins Calmodulin Other Ca2+- binding proteins Alters protein activity Exocytosis Movement Chemical signal Ca2+ in cytosol increases. Voltage-gated Ca2+ channel opens. Novel Signal Molecules: Calcium Figure 6-15 (1 of 5) Extracellular fluid Intracellular fluid Electrical signal Voltage-gated Ca2+ channel opens. Novel Signal Molecules: Calcium Figure 6-15 (2 of 5) Extracellular fluid Intracellular fluid Electrical signal released from intracellular Ca2+ stores Chemical signal Voltage-gated Ca2+ channel opens. Novel Signal Molecules: Calcium Figure 6-15 (3 of 5) Extracellular fluid Intracellular fluid Electrical signal released from intracellular Ca2+ stores Chemical signal Ca2+ in cytosol increases. Voltage-gated Ca2+ channel opens. Novel Signal Molecules: Calcium Figure 6-15 (4 of 5) Extracellular fluid Intracellular fluid Electrical signal released from intracellular Ca2+ stores Ca2+ binds proteins Calmodulin Other Ca2+- binding proteins Chemical signal Ca2+ in cytosol increases. Voltage-gated Ca2+ channel opens. Novel Signal Molecules: Calcium Figure 6-15 (5 of 5) Extracellular fluid Intracellular fluid Electrical signal released from intracellular Ca2+ stores Ca2+ binds proteins Calmodulin Other Ca2+- binding proteins Alters protein activity Exocytosis Movement Chemical signal Ca2+ in cytosol increases. Voltage-gated Ca2+ channel opens. Novel Signal Molecules: Gases Nitric oxide (NO) Activates guanylyl cyclase Formation of cGMP Acts as neurotransmitter and neuromodulator in brain Produced by endothelial cells Diffuses into smooth muscle and causes vasodilation Novel Signal Molecules: Gases Carbon monoxide (CO) Also activates guanylyl cyclase and cGMP Targets smooth muscle and neural tissue Hydrogen Sulfide (H2S) Targets cardiovascular system Garlic is major source of precursors Novel Signal Molecules: Lipids The arachidonic acid cascade produces lipid messengers Figure 6-16 Novel Signal Molecules: Lipids Leukotrienes Role in asthma and anaphylaxis Prostanoids Prostaglandins Sleep, inflammation, pain, fever Thromboxanes Nonsteroidal anti-inflammatory drugs (NSAIDs) help prevent inflammation by inhibiting cyclooxygenase (COX) Modulation of Signal Pathways Specificity and competition Agonist versus antagonist Multiple receptors for one ligand Alpha receptor Vasoconstriction Beta receptor Vasodilation Modulation of Signal Pathways Agonist versus antagonist Figure 6-17 The primary ligand activates a receptor....
View Full Document

Page1 / 51

chapter6b Communication, Integration,and Homeostasis 2 -...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online