conj402_exam1_2011 Neuro

conj402_exam1_2011 Neuro - CONJOINT 402 LAB TIME EXAM ONE...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 8
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 10
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: CONJOINT 402 LAB TIME EXAM ONE NAME January 28*“, 2011 Following directions on the mark-sense form, write your name, student number and major (PP=Pharmacy; SS=Special Permission) in the blanks and fill in the bubbles. On the blanks above, write your lab section and name. In addition, write your name on the back of this exam. When finished with the test, place the mark—sense form inside the exam form and turn in the exam and mark-sense form' together. FlLL-lN THE BLANKS: Write your answers on this page. (2 points each) A. Name an ion, other than Na+, that has a positive equilibrium potential. B. Where is the periagueductal gray found? C. Name a common cause of axonal peripheral neuropathy. D. Name a specific type of sensation that is disturbed in tabes dorsalis. E. Name any drug that will bind to the same type of receptor as does naloxone. ~F. One factor thatinfluences the movement of an io_n across a membrane is its concentration gradient. Name the second factor. G. What is out place in benign paroxysmal positional vertigo? H. What structure is affected by Meniere’s disease? I. Refer to projected figure A. Notice several postsynaptic potentials are stacked on top each other. What is this called? l. Refer to projected figure B. What is shown? Page 1 of 10 SHORT ANSWER Write your ansWers on thispage. K. The line drawing below shows a sensory stimulus to a Meissner’s corpuscle that lasts 0.1 second. Draw in the expected change in the membrane potential in the sensory dendrites. Assume the stimulus is strong enough to cause action potentials, so be sure to draw these in and label. Finally, describe how your figure shows sensory adaptation. (4 points) +60 0 -70 v I time of stimulus I on off I L. Below is a typical cell. Indicate the: (4 points) 0 relative concentrations of Na+ and K+ inside and outside the cell 0 protein that maintains the above ion concentrations 0 relative permeabilities of the resting membrane to Na+ and K+ o resting membrane potential. M. Briefly indicate what is shown by the figure to the right. (2 points) KS1 I (a separated a3; 6... ~- ,: , by a k") {'3 distance {g Page 2 of 10 STARTING Now, PLACE ALL ANSWERS ON THE MARK-SENSE FORM MULTIPLE CHOICE: Choose the BEST answer. (2 points each) 1. if you read that a neurotropin was used as a drug in a study, which one of the following best describes the type of effect caused by the drug? a. glutamate agonist b. NMDA antagonist c. GABA antagonist d. morphine agonist e. growth factor 2. Which one Of the following is most closely associated with "excitotoxicity”, such as might occur following a stroke? a. GABA b. substanceP c. glutamate d. enkephafin e. neurotropin 3. Which one ofthe following best describes how activation of an NMDA receptor might activate casp'ases in certain circumstances? (choose best) a. synthesis of ubiquitin rupture of plasmamembrane misfolding of proteins Ca” enters cell 9 o.§3 U lack of oxygen 4. Which one of the following is most closely connected to Parkinson’s disease? a. dopamine b glutamate C GABA d. gabapentin e naloxone Page 3 of 10 5. Which one of the following involves degeneration of neurons in the spinal cord (but NOT degeneration of neurons in the basal ganglia)? (choose best) a. Huntington’s disease b. amyotrophic lateral sclerosis (ALS) c. Parkinson’sdisease 6. In a resting cell, which one ofthe following has the most ungated ion channels? a. Ca++ b. KJr c. Na+ 7. Let’s say the membrane potential of a neuron is -70 mV. At this membrane potential, in what fl direction will K+ move through any open ion channels? Assume the equilibrium potential for K+ is -90 mV. a. K moves inward . . + moves ou w b K t ard c. K+ moves neither outward nor inward 8. What factor gates the ion channels that cause a postsynaptic potential? a. mechanically gated b. ligand gated c. temperature gated d. ‘ voltage gated e. allofthe above 9. Given that the Cl' equilibrium potential is —70 mV and the membrane potential is -70 ' mV, what is the net effect if Cl‘ ion channels open? a. Cl" moves inward b. Cl' moves outward c. Cl" moves neither inward nor outward 10. Given that the Na+ equilibrium potential is +60 mV and the membrane potential moves from its resting level to +30 mV, in what direction will Na‘r now move through 'any open Na+ channels? a. Na” moves inward b. Na+ moves outward c. Na+. moves neither inward nor outward Page 4 of 10 11. Which one ofthe following is TRUE about an equilibrium potential? (choose best) a. b. 12. Refer to the figure to the right. Which one of the following is shown? a. b c. d. e In some cases, an equilibrium potential lies above the threshold for an action potential. in some cases, an equilibrium potential lies below the threshold for an action potential. The opening of an ion channel causes the membrane potential to move towards the equilibrium potential ofthe ion moving through the channel. When the membrane potential of a cell moves to the equilibrium potential for an ion, the membrane potential exactly counterbalances diffusion ofthe ion due to the concentration gradient. ALL of the above are true mechanically gated ion channel facilitated diffusion transporter active transporter ligand gated ion channel voltage gated ion channel 13. in which one of the following disorders is damage associated with a breakdown in the blood brain barrier, followed by white blood cells binding to the endothelium and moving into the brain? (Choose best‘) a. b. c. d. Alzheimer’s disease multiple sclerosis Charcot—Marie-Tooth disease Huntington’s disease 14. Which one of the following afferent neurons has the fastest rate of sensory adaptation? a. b. c. d. e. olfactory neuron detecting a typical smell 'proprioceptor sensing length of quadriceps muscle while standing temperature sensor in skin detecting air temperature Meissner’s corpuscle sensing vibration C afferent pain sensor Page 5 of 10 15. Which one ofthe following determines the threshold in a neuron? a. equilibrium potential for K+ b equilibration potential for Cl' c membrane potential at which voltage gated Na+ channels open d. permeability of Na+ relative to permeability of K e concentration of Na+ inside neuron 16_. Suppose a neurotransmitter causes a slow postsynaptic potential. To which one of the following might the neurotransmitter bind? a; ungated ion channel b. voltage gated Na+ channel c. ligand gated Cl" channel cl. ligand gated K+ channel e. seven transmembrane domain protein 17. Which one of the following is attacked by botulinus toxin? a. voltage gated Na+ channel b SNARE protein c voltage gated Ca” channel d. amyloid precursor protein e capsaicin receptor 18. Which one of the following best describes paresthesia? a. double vision b lack of coordination ' c fast eye movements alternating with slow eye movements d. tingling or burning abnormal sensation . e speech dysfunction 19. A patient feels disconcerting pain when the skin is lightly brushed in a stimulus that would normally be felt as light toUch. What is this symptom called? a. sclerosis b. scotoma c. allodynia d. dystonia e. paresthesia Page 6 of 10 20. 21. 22. What factor is responsible for closing the K+ channels that participate in the action potential? a. inactivation depolarization decreased K+ concentration in neuron increased Na+ concentration in neuron {021.co- return of membrane potential to near resting level Which one of the following is the target of local anesthetics? a. voltage gated Na+ channels acetylcholinesterase myelin SNARE proteins presynaptic reuptake transporters 513de Which one of the following is found accumulating in a developing plaque in multiple . sclerosis? (choose best) 23. 24. a. neutrophils b. Tcells c. mast cells d. 'astrocytes I e. Schwann cells Which one of the following ion channels create a slow postsynaptic potential because it only opens following prolonged depolarization? a. acetylcholine receptor on skeletal muscle b. GABA receptor c. NMDA receptor cl. glutamate receptor in dorsal horn responding to A—delta pain afferent e. five subunit serotonin receptor Which one of the following ions do you suppose moves through the channels opened by the inhibitory neurotransmitter GABA? a. Cl" b. Ca++ c. Na+ Page 7 of 10 25. Which one the following would be most likely to reduce the flow of’pain information to the brain from the feet? a. damage to the dorsal portion of the thoracic spinal cord b. damage to the ventral portion ofthe thoracic spinal cord 26. Which one ofthe following is most closely associated with inflammation? a. A—alpha afferent b A-beta afferents c. A—delta afferents d C afferents 27. Which one of the following releases glutamate? a. hair cells in cochlea ' ' cones in retina A-delta afferents C afferents ALL of the above {DQDC’ 28. Refer to the figure below. Which one of the following is an inhibitory synapse? a. A b. B c. C ' A mmwmmmif 2mm V: J afla Page 8 of 10 29. Which one of the following best describes referred pain? a. - Pain arises from an internal organ such as the heart. b. Pain information crosses the spinal cord to the other side before ascending to the brain. I g c. Stimulation of skin touch sensors reduces pain felt from stimulation of nearby pain sensors. d. Pain that is neuropathic. e. Pain is constantly mentioned by the patient. 30. A clinician looks into someone’s eyes with an opthalmoscope and sees edema and lipids, giving the appearance of spots of "cotton wool”. Which one ofthe following is likely the cause? I ' a. glaucoma b. hyperopia c. Alzheimer’s disease d. diabetes e. cataraCts 31. Which one of the following is treated with anti-VEGF antibodies? a. cataracts glaucoma presbyopia "wet" macular degeneration {DQQC‘ “dry” macular degeneration 32. Which one of the following is true of_v_v_et macular degeneration but not dry? a. drusen deposits ' b degeneration of rods and cones c blood vessel growth d. loss of peripheral vision e difficultyseeing small details Page 9 of 10 33. _As the ciliary muscle of the eye contracts, which ofthe following occurs? (choose best) ' a. Ifthe subject has hyperopia, a distant image can be brought into focus. b. The focal point ofthe light moves closer to the lens. c. If a subject has hyperopia, a close object, such as a book, may not be brought entirely into focus. d. If a subject has presbyopia, a close object, such as a book, may not be brought into focus. e. ALL of the above occur ' 34. Which of the following occurs during a receptor potential in a rod following the absorption of light by rhodopsin? (choose best) ' a. cyclic GMP removed, allowing ion channel to close depolarization of rod phosphodiesterase action stopped more glutamate released {unpo- ALL of the above occur 35. Refer to the figure to the right. What is shown by the label "X"? a. crista ' b. phosphodiesterase c. trabecular meshwork d. otoconia e. cupula hairceI: PLACE MARK-SENSE FORM INSIDE EXAM AND TURN THEM IN TOGETHER. Page 10 oflO ...
View Full Document

This note was uploaded on 01/03/2012 for the course CONJ 402 taught by Professor Thomaslinder during the Fall '10 term at University of Washington.

Page1 / 10

conj402_exam1_2011 Neuro - CONJOINT 402 LAB TIME EXAM ONE...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online