conj402_exam2_2007_answers

conj402_exam2_2007_answers - CONJOINT 402 LAB TIME I! ....

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 8
Background image of page 9
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: CONJOINT 402 LAB TIME I! . EXAM # 2 NAME February 16th 2007 Following directions on the mark—sense form, write your name, student number and major (PP=Pharmacy; SS=Special Permission) in the blanks and fill in the bubbles. On the blanks above, write your lab section and name. In addition, write your name on the back of this exam. When finished with the test, place the mark-sense form inside the exam form and turn in the exam and mark-senseform together. FILL-IN THE BLANKS: Write our answers on this_p_age. (2 points each) . Rigor mortis'occurs when is depleted after death. P . Name the {Ca++ binding protein of the thin filament in skeletal muscle. m w (A i A . Name the disorder in which antibodies cause a decrease _ in the number of active acetylcholine receptors at the (\A x,‘ «glider/t [ 0x CA (CU/f S neuromuscular junction. . This is the name for muscle precursor cells that fuse . - _ during development to form skeletal muscle fibers. 0-5 J" 5 . This part of the brain compares input from the motor _ cortex about the intended movement with sensory 1 inputs about motor performance. Damage to this Ca 7Q 6“ V. m region leads to uncoordinated movement and action tremor. _ A . Strength training (for instance, weight lifting) causes an increase in muscle fiber diameter known as _.___.___.L______l Periheth G. This is the name for the maximal muscle fiber contraction that occurs in response to a volley of action . I . potentials (many action potentials in rapid succession). ’LQ‘LOTV‘ u S H. Which term describes a sudden loss of skeletal muscle { tone? (Hint: this is a characteristic symptom of mat/Ta? €¥ 7, narcolepsy.) Name the motor disorder in which degeneration in part , of the basal ganglia leads to chorea (uncontrolled RU Wk W3 “\S Chg “EL dance-like movements), hypotonia, and dementia. Name the type of aphasia in which patients have difficulty producing speech, while still having P) (b C 93 S (N ccg t m reasonably good comprehension of simple speech. g Page 1 of 8 SHORT ANSWER ' r’ . Write your answers on this page. ' K. Describe the sequence of events whereby an action potential in a skeletal muscle fiber . leads to an increase in Ca++ in the cytosol. Your answer should include a discussion of the role of sarcoplasmic reticulum and T-tubules. (3 points) 0. pk” 3,,ng ".3 Comic did on}? Teams; ‘ h Ulioolcarizakiw CWRS 0' (fiVviQ-(Mwhwwtl [iii/frat .m M “We‘w‘e W V“ (gawiifiiitlm). {ARV/ad’s wit/bu 6.4 MP1 SR C35" C‘Knyth‘ CMSCIKS - 0‘03 V‘ palaces-C CrH' M5 9145054' v L. Skeletal muscles possess a unique mechanism for rapidly generating ATP in the first few seconds of muscle activity. Show the chemical reaction in which ATP is rapidly generated. What enzyme catalyzes this reaction? (3 points) a? +ADP“——‘" it”? Graph/l1, «PM asphalt—e. 7l M. In the stretch reflex, stretch of a muscle leads to contraction of that muscle. i. Diagram the circuitry underlying this behavior. ii. Diagram how reciprocal innervation prevents activation of antagonist muscles .during the reflex. Be sure to label all the components of the circuit. (4 points) {Ere meal bewempgi‘xavv. r. eflvwbgi] OI: (Wilflb’k‘glj \fl . ' hibi—lxar km... 3 mk’néurlm (“l MN +0 W1 [El :5me - . _ V most/[L g+)~tj'ou3+ lMuS'c/lJZ 2/ /Pag2/fl)f8 Multiple choice key 1 . AAAA—AAA—A—AA figmmwmmbwmgommflmmhmm wwwwmmmmmmm 8N—‘OCOGJNCDOW-b-wk) 00 A B C C B C D A B C B A A C C A A C A E D B A A A D D C E B C D E D A D ()0 (fl STARTING NOW, PLACE ALL ANSWERS ON THE MARK-SENSE FORM MULTIPLE CHOICE: Choose the BEST answer. (2 points each) 1. When a muscle fiber shortens a. the A-band becomes narrower b. the I-band becomes narrower c. the A-band becomes wider d. the I—band becomes wider 2. The force-generating step (powerstroke) of cross-bridge cycling occurs just after (CHOOSE BEST) ATP binding to myosin ATP hydrolysis myosin binding to actin myosin dissociating‘from actin 9.0 .ch 3. In cross—bridge cycling, ATP hydrolysis causes myosin to dissociate from actin ATP hydrolysis occurs after myosin binds to actin ATP binding causes myosin to dissociate from actin ATP binding causes myosin to bind to actin 9‘???” 4. Which of the following is a filamentous protein that blocks myosin binding sites on skeletal muscle thin filaments? a. troponin b. tropomyosin c. titin d. actin e. myosin light chain 5. The activity of the CaH-ATPase is responsible for a. muscle fatigue b. excitation-contraction coupling c. relaxation d. rigor mortis 6. force generation Page 3 of8 6. What does it mean to say that the neuromuscular junction has a high safety factor? (CHOOSE BEST) a. the somatic efferent neuron action potential always causes an EPSP in the muscle fiber _ b. a single muscle fiber is innervated by multiple neurons at the neuromuscular junction ' c. the neuromuscular junction is protected from immune system attack (1. the somatic efferent neuron action potential causes an EPSP that is well above threshold 7. Under normal circumstances, one action potential in one somatic efferent will cause a. an action potential in each of the muscle fibers of the motor unit b. muscle action potentials, but only in those muscle fibers in which summation can occur 0. tetanus in all the muscle fibers of the motor unit (1. both “a” and “c” are correct 8. In a patient with myasthenia gravis, the EMG potential of a motor unit is seen to decline with repeated stimulation. This is due to a. fewer somatic efferent motor neurons firing action potentials b. fewer muscle fibers firing action potentials 0. central fatigue (1. peripheral fatigue 9. Which of the following proteins'is found in the T-tubule membrane? a voltage-gated Na+ and K+ channels b. voltage sensor involved in excitation—contraction coupling c. both a and b d. none of the above 10. What occurs when muscle tension is exactly balanced by load? a. an isotonic contraction b. an isometric contraction c. the muscle fiber generates no force 11. Which of the following best describes why maximal force is not generated during a twitch? a. Ca++ levels are dropping before the series elastic elements can be fully ' stretched b. a single action potential does not cause enough Ca++ release to activate 100% of the cross—bridges Page 4 of 8 12. Figure 1 shows the length-tension relationship in skeletal muscle. Which key principle is illustrated by the length-tension relationship? a. that tension is proportional to the number of active cross-bridges b. that as the length of the muscle increases, the load is always decreasing c. that as the length of the muscle increases, the tension is always increasing d. none of the above ........................... .. ,.,,,.,..,.....Figure 1 relative tension - . y L1 L2 L3 L4 L5 muscle length 13. Which of the following is true about fatigue in skeletal muscle cells? fatigue occurs most rapidly in the smallest muscle fibers fatigue occurs as soon as creatine phosphate is depleted fatigue is a decline in muscle performance as a result of previous activity muscle denervation causes fatigue fatigue is linked to the level of ATP in a muscle fiber 9999‘?” 14. Fast glycolytic muscle fibers have a fast contraction velocity because (CHOOSE BEST) - V a. they have a faster rate of Ca++ release from the sarcoplasmic reticulum b. they have more myofibrils 0. they express a myosin that hydrolyzes ATP at a fast rate (1. they have a faster action potential conduction rate 15. The largest somatic efferent neurons innervate which type of muscle fiber? a. fast glycolytic b. fast oxidative 0. slow oxidative d. smooth 16. Recruitment to increase force during muscle contraction involves a. activation Of more motor units b. activation of more muscle fibers per motor unit c. addition of myofibrils to increase muscle fiber diameter d. all of the above Page 5 of8 17. Which of the following is a way that smooth muscle is different from skeletal muscle? CaJr+ regulates contraction force generation depends upon cross-bridge cycling Synapses onto muscle fibers may be either excitatory or inhibitory cells contain actin and myosin filaments relaxation occurs as Ca++ is pumped out of the cytosol 9999‘?” 18. Which of these enzymes in smooth muscle is regulated by Cayr levels? a. myosin light chain kinase (MLCK) b. myosin light chain phosphatase (MLCP) 0. both MLCK and MLCP 19. Which of the following opens ligand-gated ion channels in the smooth muscle sarcoplasmic reticulum? a. calmodulin b. myosin light chain kinase c. myosin light chain phosphatase d. acetylcholine e. IP3 20. Which of the following neurons directly causes contraction in an intrafusal fiber? a. Golgi tendon organ afferent b. muscle spindle afferent 0. alpha motor neuron d. gamma motor neuron e. upper motor neuron 21. When muscles contract, muscle spindle sensitivity is maintained through activation of the (CHOOSE BEST) a. muscle spindle afferent b. gamma motor neuron 0. alpha motor neuron d. Golgi tendon organ afferent 22. In what part of the muscle spindle would you find mechanically gated ion channels? in the sensory dendrites of the muscle spindle afferent at the two ends of the intrafusal fiber in the gamma motor neuron none of the above 9*.“ 9"?” 23. Which of the following is the lLs’t stimulus for a Golgi tendon organ? a. muscle contraction b. muscle stretch Page 6 of 8 24. In the withdrawal reflex, the pain afferent excites an interneuron that (CHOOSE BEST) a. excites motor neurons that project to ipsilateral (same side) flexors b. inhibits motor neurons that project to ipsilateral flexors I c. excites motor neurons that project to contralateral (opposite side) flexors d. excites motor neurons that project to ipsilateral extensors 25. An upper motor neuron controlling leg movements has its cell body located in theleft motor cortex. Where in the spinal cord would you find the axon of this neuron? 9999‘!” c0rticobulbar tract left lateral corticospinal tract left anterior corticospinal tract right lateral corticospinal tract right anterior corticospinal tract 26. Which of the following is an example of a negative Sign (due to loss of excitatory input) that would be seen in an upper motor neuron disorder? 09.09"!” ataxia hypertonia clonus weakness in affected limb all of the above 27. All of the following are true about the primary motor cortex, EXCEPT a. b. C. d. 6. it is located in the precentral gyrus it contains neurons that synapse directly onto spinal cord motor neurons the left primary motor cortex mainly controls movements on the left side of the body there are more neurons dedicated to motor control of the hand versus the shoulder ' ' it has a somatotopic organization 28. Identify the term that means “slowness of movement”. a. b. c. d. 6. ataxia clonus chorea aphasia bradykinesia 29. This protein has been found to accumulate in Lewy bodies. 99.0572» huntingtin alpha-synuclein dopamine transporter acetylcholinesterase superoxide dismutase Page 7 of8 30. Rigidity from hypertonia is a characteristic of {DP-“9.0"?” cerebellar disorders narcolepsy Parkinson’s disease Huntington’s disease both cerebellar disorders and Huntington’s disease 3 1. Which of the following is true about the orexin-secreting neurons of the hypothalamus? EFL-99".” increased activity in these neurons is correlated with REM sleep they inhibit cells in the arousal—promoting nuclei they excite cells in the sleep-promoting nucleus they excite cells in the arousal-promoting nuclei degeneration of orexin—secreting neurons causes insomnia 32. Which of the following drugs is used to decrease daytime sleepiness in narcolepsy? {DP-.097?” benzodiazepine zolpidem antidepressant antihistamine modafinil 33. All of the following occur with REM sleep, EXCEPT a. b. c. d. e. increased firing of GABA-releasing neurons in the anterior hypothalamus desynchronized EEG ' lack of skeletal muscle tone : increased firing of norépinephn'ne and dopamine—releasing neurons of the hypothalamus rapid eye movement 34. Global aphasia results from large brain lesions. What motor symptoms typically accompany global aphasia? ' ' a. b. weakness and paralysis on the right side of the body weakness and paralysis on the left side of the body 35. The arcuate fasciculus (CHOOSE BEST) 99.0.69 is specifically damaged in conduction aphasia is a tract of axons linking speech areas is necessary to link language comprehension with language expression all of the above are true none of the above PLACE MARK-SENSE FORM INSIDE EXAM AND TURN THEM IN TOGETHER. Page 8 of8 ...
View Full Document

This note was uploaded on 01/03/2012 for the course CONJ 402 taught by Professor Thomaslinder during the Fall '10 term at University of Washington.

Page1 / 9

conj402_exam2_2007_answers - CONJOINT 402 LAB TIME I! ....

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online