7 cell_cycle_07_aris

7 cell_cycle_07_aris - Medical Cell and Tissue Biology, BMS...

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Medical Cell and Tissue Biology, BMS 6110C John P. Aris, Ph.D. Rm B1-8, 392-1873, johnaris@ufl.edu Chapter 3 Cell Cycle
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Cancer Mortality Statistics Source: American Cancer Society 2007 Estimated US Cancer Deaths Men 289,550 Women 270,100 26% 15% Breast 10% 6% Pancreas 6% Ovary 4% Leukemia 3% Non-Hodgkin lymphoma 3% Uterine corpus 2% Brain/Nervous system 2% Liver & bile duct 23% All other sites 31% Prostate 9% Colon & rectum 9% Pancreas 6% Leukemia 4% 4% bile duct Esophagus 4% Urinary bladder 3% Non-Hodgkin 3% lymphoma Kidney 3% All other sites 24%
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Skin Cancer Skin cancer - most common form of cancer in the US Major types - basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM) Prognosis - BCC and SCC are highly curable (>90%), MM is not (MM accounts for 75% of deaths from skin cancer) Mortality - ~10,000 Americans Risk factors - exposure to UV light is most important factor Prevention - consistent use of sun-protective practices (a survey sponsored by the CDC found that ~43% of white children under age 12 had at least one sunburn during 2004)
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Evading Apoptosis Sustained Angiogenesis Cancer Self-sufficiency in Growth Signals Tissue Invasion and Metastasis Limitless Replicative Potential Insensitivity to Anti-growth Signals Hanahan and Weinberg proposed that normal cells must acquire six phenotypes to become malignant (Hanahan and Weinberg, 2000, Cell 100 :57). Characteristics of Cancers
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Cancer and Cell Cycle Regulation Many of the genes found to be mutated in cancer cells encode proteins that regulate the cell cycle . Mutations that increase cell proliferation exert their
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This note was uploaded on 01/04/2012 for the course ANT 610C taught by Professor Johnaris during the Spring '10 term at University of Florida.

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7 cell_cycle_07_aris - Medical Cell and Tissue Biology, BMS...

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