8 ct_1_07_aris - Medical Cell and Tissue Biology BMS 6110...

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Medical Cell and Tissue Biology BMS 6110 John P. Aris, Ph.D. Rm. B1-8, 392-1873, johnaris@ufl.edu Reading: Ross & Pawlina, 5 th Ed, Ch. 6 Connective Tissue 1
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Connective Tissue Characteristics - cells and extracellular matrix (ECM) ECM - protein fibers, "ground substance", tissue fluid Distribution - lies between basal lamina of epithelia and external lamina of muscle and nerve supporting cells Mammary gland (Masson stain) Epiglottis (Mallory-Azan stain)
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Connective Tissue Classification Specialized CT Adipose Blood Bone Cartilage Hemopoietic Lymphatic Reticular Embryonic CT Proper Loose Dense Irregular Regular
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Connective Tissue Functions Structural support “Hard” connective tissues “Soft” connective tissues Energy storage Adipose tissue Medium for exchange Tissue fluid Avascular tissue support Defense and protection Inflammatory response Immune response Wound repair
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Embryonic Connective Tissue Mesenchyme - embryonic connective tissue derived from mesoderm and neural crest cells (“ectomesenchyme”) Mesenchyme cells give rise to all CT cell types (as well as non-CT cell types, such as endothelium and muscle) Larson Fig 4-12 Larson Fig 3-3
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Loose Connective Tissue General characteristics - more cells, less collagen Lamina propria in intestinal villus Intestinal villi
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Dense Connective Tissue General characteristics - more collagen, less cells Irregular - collagen fibers less oriented Regular - collagen fibers more oriented Distinguished by density and organization of collagen fibers Dense regular CT in tendon Dense irregular CT in dermis
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Connective Tissue Components Cells Extracellular matrix (ECM) Protein fibers Collagen Elastic Reticular Ground substance Proteoglycans Hyaluronic acid Adhesive proteins Tissue fluid
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Connective Tissue Cells Resident (or fixed) cells - cells that reside in CT Fibroblast (including tendinocytes, reticular cells) Adipocyte Macrophage (differentiates from monocyte) Mast cell Plasma cell (differentiates from B lymphocyte) Undifferentiated cell (mesenchymal cell) Transient (or wandering) cells - cells that migrate into CT Neutrophil Eosinophil Basophil Lymphocyte Monocyte
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Collagen fibers Composed of fiber-forming collagen proteins Type I collagen fibers are present in loose and dense CT Many types of collagen proteins do not form fibers Elastic fibers Composed of elastin and fibrillin proteins Fibers are thinner than collagen fibers Elastic fibers are deformable (can stretch and recoil) Reticular fibers Composed of type III collagen Form loose mesh-like network of fibers Do not form thick bundles of fibers Extracellular Fibers
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Mesenchyme Derivatives Cells derived from mesenchyme (embryonic CT) are “resident” cells that live and die where they were born Not CT cells
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8 ct_1_07_aris - Medical Cell and Tissue Biology BMS 6110...

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