9 ct_2_07_aris - Medical Cell and Tissue Biology BMS 6110...

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Medical Cell and Tissue Biology BMS 6110 John P. Aris, Ph.D. Rm. B1-8, 392-1873, johnaris@ufl.edu Reading: th Ed, Ch. 6 Connective Tissue 2
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Connective Tissue Components Extracellular matrix Fibers Collagen Elastic Reticular Ground substance Glycosaminoglycans Hyaluronic acid Proteoglycans Keratan sulfate Chondroitin sulfate Adhesive proteins Fibronectin Laminin Tissue fluid Cells Resident (fixed) Fibroblast Adipocyte Macrophage Mast cell Plasma cell Undifferentiated cell Transient (wandering) Neutrophil Eosinophil Basophil Lymphocyte Monocyte
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Collagen fibers Composed of fiber-forming collagen proteins Type I collagen fibers are present in loose and dense CT Many types of collagen proteins do not form fibers Elastic fibers Composed of elastin and fibrillin proteins Fibers are thinner than collagen fibers Elastic fibers are deformable (can stretch and recoil) Reticular fibers Composed of type III collagen Form loose mesh-like network of fibers Do not form thick bundles of fibers Extracellular Fibers
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Elastic Connective Tissue Elastic fibers (mesentery) Elastic lamellae (aorta wall)
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Elastic Fibers Elastic fiber - central core surrounded by microfibrils Central core consists primarily of the protein elastin Microfibrils contain the protein fibrillin and are ~10 nm wide Elastin is deposited after microfibrils have been formed
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Elastin Elastin - long (~750 a.a.), hydrophobic protein rich in glycine and proline, all of which favor a compact folded conformation Intermolecular covalent crosslinking distributes applied stress across many elastin protein molecules, which then unfold
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Fibrillin Fibrillin is a major protein of elastic fiber microfibrils Fibrillin proteins associate laterally and head-to-tail Fibrillin is a multidomain protein consisting of tandem repeats rich in cysteines, which from disulfide bridges Mutations in fibrillin 1 gene cause Marfan syndrome, which affects tissues rich in elastic fibers (e.g., aorta wall) Fibrillin protein Folded repeat domain Elastic fiber Microfibril Fibrillin protein
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Ground Substance Ground substance surrounds fibers in the extracellular matrix Components - hyaluronan, proteoglycans, adhesive proteins Paradigm - ground substance provides resistance to compression whereas collagen fibers provide tensile strength Fibroblasts - synthesize many ground substance molecules EM of ground substance and collagen fiber in cartilage
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GAGs Glycosaminoglycans - unbranched polysaccharide chains Disaccharide repeat unit - 1 of 2 sugars is an amino-sugar High negative charge - due in part to sulfates on sugars Not all GAGs are ECM structural components (e.g., heparin)
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Hyaluronan (Hyaluronic Acid) Abundant, long, unsulfated GAG (up to 25,000 sugars long) Long extended anionic molecule forms hydrated gel in ECM
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This note was uploaded on 01/04/2012 for the course ANT 610C taught by Professor Johnaris during the Spring '10 term at University of Florida.

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9 ct_2_07_aris - Medical Cell and Tissue Biology BMS 6110...

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