23 lymphatic2_lecture07print_nxpowerlite_

23 lymphatic2_lecture07print_nxpowerlite_ - Lymphatic...

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Lymphatic System II Dr. T. G. Hollinger Medical Cell and Tissue Biology ©Copyright, Thomas G. Hollinger, Gainesville FL 2007
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Lymphatic ‘Organs’ Primary organs Bone marrow (Seen in hematopoiesis laboratory) B and T lymphocytes formed in the marrow B cells mature here Thymus T cells mature here Secondary organs Lymph nodes Spleen Tonsils Lymphatic nodules are not organs, but are very important, perform many of the same functions ©Copyright, Thomas G. Hollinger, Gainesville FL 2007
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Questions You Should Be Able To Answer About Lymphatic Organs What is the basic function of this organ? How do lymphatic cells move through the organ? How is the blood flow organized? What functions happen in each part of the organ? ©Copyright, Thomas G. Hollinger, Gainesville FL 2007
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Development of the Thymus 1. Ectoderm of 3 rd pharyngeal cleft grows inward 2. Ectoderm surrounds the endoderm of the 3 rd pharyngeal pouch (also inf. Parathyroid formed) 3. The ectoderm (cervical vesicle) fully surrounds the endoderm 4. Capsule and incomplete trabeculae forms from the mesoderm 5. Stoma comes from EPITHELIUM 6. Epithelial cells attract T cells (precursors), dendritic cells and macrophages 7. Involutes after puberty, T cell progeny carry on ©Copyright, Thomas G. Hollinger, Gainesville FL 2007
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Development of the Thymus ©Copyright, Thomas G. Hollinger, Gainesville FL 2007 Kierszenbaum 10-14
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Thymus Structure Consists of lobes with incomplete lobules Cortex (Epithelial cells from ectoderm) and medulla (Epithelial cells from endoderm) Blood thymus barrier in cortex allows T cell development to occur there ©Copyright, Thomas G. Hollinger, Gainesville FL 2007 Blood flow: Afferent Efferent Lymph flow: Efferent
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Thymus Function Double negative cells become double positive Epithelial cells express MHC I and II MHC II required to form CD4+ cell MHC I required to form CD8+ Cells Ag – T cells that recognize MHC are allowed to mature T cell that don’t recognize MHC become apoptotic (95%) Few mature T cells are found in the medulla because these
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23 lymphatic2_lecture07print_nxpowerlite_ - Lymphatic...

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