25 gi_epithelium_07_nxpowerlite_

25 gi_epithelium_07_nxpowerlite_ - Gastrointestinal System...

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Gastrointestinal System The Epithelial Barrier Epithelial cells are structurally and functionally polar. Homeostasis of the epithelium of the GI tract requires a balance between proliferation, growth arrest, and programmed cell death.
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Objectives to understand the role of cell polarity in the function of the epithelium to appreciate how cell polarity is maintained during mitosis to understand the dynamic state of an epithelium to recognize the events of epithelium regeneration to understand the regulatory events of mitosis and apoptosis
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Kierszenbaum, Fig. 15-7 Gastrointestinal System
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Epithelium of the Stomach There exists three primary cell types in the epithelium of the stomach: goblet cells, parietal cells, and Chief cells. Chief cells are responsible for the secretion of pepsinogen into the stomach lumen. Merocrine secretion is mediate by calcium. Parietal cells are responsible for the secretion of HCl into the stomach lumen. HCL secretion requires cytosolic carbonic anhydrase, two ion uniporters at the apical surface, one ion antiporter at the basal surface, and a H/K ATPase at the apical surface.
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Fundic Stomach M u c o s a Muscularis mucosa Pit Neck Gland
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Gastric Pit Gastric Gland Surface Mucous Cells Parietal Cell Mucous Neck Cells
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Fundic Stomach M u c o s a Muscularis mucosa Pit Neck Gland
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Muscularis mucosa Inner Circular Outer Longitudinal Parietal Cell Chief Cell
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Chief Cell: Secretion of pepsinogen (an inactive form of pepsin) is stimulated by acetylcholine. RER SV SV L N
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Ross, Fig. 2.26
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Protein Secretion in a Polarized Epithelial Cell Apical Surface Basal Surface Constitutive Secretion Regulated Secretion Ca +2 RER Golgi
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Cell: Secretion of hydrochloric acid (HCl) is stimulated by gastrin, acetylcholine, and histamine. L
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25 gi_epithelium_07_nxpowerlite_ - Gastrointestinal System...

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