25 liver_07_nxpowerlite_

25 liver_07_nxpowerlite_ - Glands of the Gastrointestinal...

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Glands of the Gastrointestinal Tract Serous and mucous secretions of salivary glands, liver and pancreas help maintain the optimal environmental conditions within the GI tract for digestion and absorption of food substances.
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Objectives to understand the multifunctional aspects of the liver in maintaining circulating levels of amino acids and glucose, in digesting food substances, in detoxification, and in the immunological response. to appreciate the how portal circulation assists in the function of the liver to understand functional roles of the salivary glands and pancreas in digesting food substances
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Outline There exists three primary cell types in the liver: hepatocytes, Kupffer cells, and endothelial cells. There are three types of liver lobules based on exocrine function, endocrine function, and blood flow. The liver has a portal circulation The liver has both endocrine and exocrine functions. Liver has the capacity to regenerate. Bile produced by the liver is stored and concentrated within the gall bladder.
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The Liver the largest gland of the body (about 2% of the body weight) receives both venous blood through portal vein (75%) and arterial blood through hepatic artery (25%) surrounded by a well defined thin capsule functions as exocrine gland because it secretes bile and as an endocrine gland because it secretes plasma proteins
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Liver functions Metabolic Functions Homeostasis of circulating amino acids, carbohydrates, lipids and vitamins Regulation of serum levels of lipids and hormones by endocytosis Production of urea Endocrine Functions Synthesis and secretion of serum proteins Albumin, transferrin, prothrombin, fibrinogen, retinol-binding protein, GH-resisting factor, VLDL, LDL, HDL Converts tetraiodothyronine (T4) to triiodothyronine (T3) Converts vitamin D to circulating 25-hydroxycholecalciferol Exocrine Functions Production of bile Transport of polymeric IgA Detoxification Functions Oxidation (addition of -OH or -COOH groups by cytochrome P450) Conjugation with glycine, taurine, or glucuronic acid Phagocytic Functions Foreign organisms Aged red blood cells Hemopoiesis (6 th week to 7 th month embryo)
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Kierszenbaum, Fig. 17-10 Venous Portal Circulation of the Liver
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Lobulation of the Liver Portal Lobule : based on excretory function, triangle with central veins at corners and a portal triad at the center Classical Lobule : based on endocrine function, hexagon with portal triads at the corners and the central vein at the center Liver Acinus : based on blood flow, diamond shaped with two central veins and two portal triads at the apices
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Kierszenbaum, Fig. 17-11
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CV CV CV CV CV PT PT PT PT PT 1 3 3 Zone 1 cells are the first to receive blood, the first to regenerate and last to die. Stem cells present in this zone.
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This note was uploaded on 01/04/2012 for the course ANT 610C taught by Professor Johnaris during the Spring '10 term at University of Florida.

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25 liver_07_nxpowerlite_ - Glands of the Gastrointestinal...

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