27 kidney_07_web - Urinary System Ion and nutrient...

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Unformatted text preview: Urinary System Ion and nutrient transport The kidney functions to resorb ions and nutrients from the glomerulus filtrate. The transport of ions and nutrients into and through the cell is mediated by membrane channels. Objectives To understand the organization of the kidney nephron and collecting tubules. To appreciate how membrane transporters are essential for kidney function. To describe how membrane transporters transport ions and nutrients into and out of the cell. Kidney Functions Conservation of body fluids and salts and removal of metabolic wastes (urea, uric acid, and creatinine). Synthesis of erthyropoietin (EPO) which stimulates erythropoiesis. Synthesis of renin which regulates blood pressure and blood volume. Hydroxylation of vitamin D to its active form. Outline The kidney lobe is an organization of nephrons and collecting tubules into a cortex and medulla. The cortical portion of the lobe is further organized into lobules which are bordered by interlobular vessels and contain a centralized medullary ray. The renal vascular system is an arterial portal system. The kidney nephron includes the renal corpuscle, proximal (convoluted and straight) tubules, distal (convoluted and straight) tubules, and thin tubules. Organization of the kidney nephron and collecting tubules within the cortex (cortical labyrinth and medullary rays) and the medulla (medullary pyramid). Kidney Architecture Kidney Lobe : medullary pyramid and associated cortical tissue including that within the adjacent renal columns Kidney Lobule : central medullary ray and surrounding cortical material Ross Fig 20.1 Renal Artery Interlobar Artery Arcuate Artery Interlobular Artery Afferent Arterioles Efferent Arterioles Peritubular Cap. Interlobular Vein Arcuate Vein Interlobar Vein Renal Vein Glomerulus (Bowmans Space) Prox. Conv. Tubule Prox. Straight Tubule Thin Segments Distal Straight Tubule Distal Conv. Tubule Collecting Duct Ureter Efferent Arterioles Art. Rectae Spuriae Vasa Recta Arcuate Vein Interlobar Vein Renal Vein Blood flow Capillaries Cortical Glomeruli Capillaries Juxtamedullary Glomeruli Kierszenbaum, Fig. 14-1 refer to Ross Fig 20.21 Blood flow Kierszenbaum, Fig. 14-2 Kidney Liver Pituitary Uriniferous Tubule: Nephron renal corpuscle (RC) proximal convoluted tubule (PCT) proximal straight tubule (PST) thin segments (TS) distal straight tubule (DST) distal convoluted tubule (DCT) Collecting Duct (CD) Cortical nephron Juxtamedullary nephron Medullary Ray: proximal straight tubule distal straight tubule collecting duct Cortical Labyrinth: renal corpuscle proximal convoluted tubule distal convoluted tubule Medullar Pyramid: proximal straight tubule distal straight tubule thin segments collecting duct Ross Fig 20.3 Arcuate artery Cortex Medulla Arcuate vein Cortex of the Kidney RC, renal corpuscle CL, cortical labyrinth MR, medullary ray CL CL RC MR MR PS CD DS DS PS Medullary Ray Cortical Labyrinth PC PC...
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27 kidney_07_web - Urinary System Ion and nutrient...

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