28 pkd_aris_2007 - Polycystic Kidney Disease Renal...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
Polycystic Kidney Disease John Aris 9 November 2007 Renal Epithelial Cells and the Monocilium
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Polycystic Kidney Disease Incidence Worldwide - 12.5 million children and adults US - 600,000 Americans Manifestations Fluid-filled cysts in kidneys; cysts in liver; complications in other organs, such as heart and blood vessels in brain Pathology Cysts replace kidney tissue and reduce kidney function About 50% of cases progress to kidney failure (end-stage renal disease) and require dialysis or transplantation Treatment None
Background image of page 2
PKD Classification Autosomal Dominant PKD (ADPKD) Most common inherited form (~90% of all PKD cases) Symptoms usually develop at age 30-40 Larger cysts form over time and grow in size Autosomal Recessive PKD (ARPKD) Rare genetic disorder (~1 in 20,000) Small cysts form in collecting tubules Symptoms begin in utero or in the postnatal period Acquired cystic kidney disease (ACKD) Not inherited Develops in association with long-term kidney problems Usually appears in later years of life
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 13

28 pkd_aris_2007 - Polycystic Kidney Disease Renal...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online