Lecture 6a - Imam. Mimrnr cartil. Sponge {trabccuian bane-...

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Unformatted text preview: Imam. Mimrnr cartil. Sponge {trabccuian bane- Inlemitinl Iamellae Circuflerenfial Iameilae Mam cairin Capillaries in Have-sign and III.I"v|;llli:rl'liln n“: Secondary Date-on ‘l' Shunt" a! arlimh ill-Him m. carnal: {Ha-Jamal" system} Micular cartilage .' ' - Concentric Diaph'ysis . hurl-Elia»? in l-la'irersian minis T' Capiliary in r b'ta‘i' Volmnn's canal . f . . Settifln DI wial amt 5w I Regional organization based on manure-cm pmximitf and mini! common filiding inflam- Micular cartilage has a Iam-eliarorganizarian with d matessive acne-s Subchondral hone Spa-fig? bone micmar cartilage and sub: hamlml bane E: Elsevler. male 31 Hahlrnev: Hetlaa‘s Ementlal Hlfitflhgf - www.5tuda1tmnwlt.cnm T Shootouottltrooh'pasot cartlhpe. Al'lictllarr l'l’falil'lfl cartilage Clrienration of collagen fibers 1'3"“? . .-. — ..—__. _-. Tangential HistologylHflrEl -___—- —-_ Calcilied can-lees 1. Url of arliurlar Martina cartilage from a developing rat tutors Emmanan Articular carnage has a complex internal structure. as well as sharing - - EMA? features with other types of htreline cartilade. 01‘ "5 lflUf DWTlti UBMCETE’U D'- jfi tones. the most superficial. uppermost zone torms the glid'rrg audace and is _ _ in contact I.rrittr the sartorial cavity {v} of the iolnt. Small round chmdrmyrtes Elastic armless {or are oriented parallel to the surface: chondrocytes in deeper zones are ’T- ' . - . - larger. more rounded. and arranged in vertical columns. The deepest zone contains caloilied cartilage [m]. which separates l'rrrallne cartilage trorn suhchondral bone. The term chondt‘m encompasses the chondroc'fie and its pericellutar and territorial rrratrirr. Lacking a perlchondriunt. articular cartilage is a variant of healine cartilage iourrd elsewhere tag. to the trachea. nasal septum. and lflflr‘fitfl. lime. mmmmcnhenangeot I ' . I ..r- . _. J-"" I" —_‘3-|.II—- "- - " Interlacr'ng strands of fibrous Darkustainr'ng elastic fibers tissue rhrougltcrul r'nntr'nr between and around lacunae IH-firE} {HERE} {El Else'rler. Deane e Hahlrnetr': Nether‘s EsseMlal Histologl' - www.ctudentconsult.com It I.“ of It!!!“ cat'tihna. In both rih {oostal} [Lam and tracheal {Hm cartilage. a penchandriurn {Pal surrounds the cartilage matrix. Blond trassets {arrows} in the penchondn urn pro-tide margen and mutants. which dtltuse into the aeascutar cartilage. Ei'tondroctrles [B] in lacunae are surrounded by a glassy I'Tlfltriit. Peripheral "Em Efillfl are GENE fldflflfl recent; by appealiional growth. In dflflflflf regions. the Calls; are “1an Sill'fll’infll Eli'tfl occm il'l tSUQElf'lEHfi “BEE. indicatiee of interstitial gown. it titration artifact causes shrinkage of chondrocytes. with clear spaces around them. 225cc. HaE. Ir Him: magnification Uh ol hear-1e cartilage from the hatches. Groups at chondroct'tes I113}. the isooerteus nests. sit in lacunae. Prenatalieo anitact cases some lacunae to appear emettr [*l- "1 other tawnae. cl‘ondracetes shrank away from wells to leave a clear perlcelltlar hale. Each call has a slight; irregular shape and contains a single nucleus. often eccentric in location. A thin rim of headache tarntorlal matrix ['l'litt la II'I me enmeaiate eic'rmry at lacunae. which indicates a huge: concen- tration of newly synthesised sultated ease. Between the choratroctrtas. the 'ntterterrltorial matte {1H3 appears more easinoprl'lic and has a typical glassy appearance. 4592. Jet“. El Elsetrier. Dealie E1 Hahimee: Hatters Essentlat l-tiilzlloct'pr — www.5tuderttconsuit.com Link protein "L Cliondroctne Hynluronic acid Chmfle Simmize‘i 3nd Proteogiycan aggregate Extracellular rriaorornoioCular Sta-crates lrpe || collagen and [matrix components} matrix proteoglycnns, whieli interact I to Form Itirdniied niterorrioieeulrir G'rmflmmflii'rflflfi _ _ matrix. oil cartilage H20 d Reslmrnl DI collagen meshworli 7' - ' "' - . sullnte ' -;§—i:/"JHJDL; - -, Chonciroitin H2 ‘ {3' _ HEB _ :"-' .- *_ HID _.-_-: Dermatan a}: H20 ' .2" } EUIFBEE I, _. HJQ ff“. I CO e H30 _. Hyaluronii: - - -- ' t L- ' “5 P'Ulfli ' acid . - ' ' ' -.-" - " 4 . Link [Mei _. a flfifl fl ' Prorooglycan N ’iiiny charge-cl GAE side chains repel one another aggregate no aura-ct writer. increasing matrix volume. Expansion limiied by collagen i'l'lilESl'IWEIl'l-L Matrix oomression pushes GAG side chains iogorher. releasing water and decreasing rnnlriri 1rolun‘ie. Decompression allows ro-errpansion of molecule and matrix I.I'izili,rrri\o E: Elsevler. more El Hahlrneti: Homer‘s Emanuel Histologr - www.5tuder1tconwlt.cum hi ucle'us pulp-35w; r’tnnultis fibrosis Ii l Lan-magtificatim Llil at an intanrertnhral disc in Imnihidihal mtiun. The dist: is hat-mu bodies of him rattabrae {'0'}. Wish are made at spongy bane. A central nuclEus pulpnaus {IE1 is smountted hit an annulus rihmis inf}. 5x. Hair I. An interwar-labial dist: column bodies of adjacml whine. The dist: hm two parts: a cemnal nucleus puipmus Cit-Misth tif wllaQEn and hydrated P65 anti an WIEF annulus fitlr'flStS of fihmcariilage composed r11I semantic tamaliae flf coith fibers. i- Llil til Maritime ET the amlus thrush at an intam‘tehral disc. Bah-men the mantimqrtes {I3} it the matrix {M} are coarse hu ndles Elf dame, InIBfISEIj' aninnphilic mitagen fiham [arrows]. which are all mianied in the same direction. The Eiungated Emmtflfifi. thund in smart ram. aria surruundad ha- a rrarmrr zone at hasmhiiic gram! suhtthantpe. Hhmcartllage- lacks t: [Jarch tiriurn. Part iii the nudaus FIJIflIJELIS {If}. Seen in the timer right. has an amwnnus appearanae. 339x. HEE .‘_ {El Elmira. (in-latte BL hiahlmev: Net-ten“: Essentiai HIStGFflgf * www.5tudmtconwit.cnm 1| Lit! at elastic cartilage in the eniglnttie et a child. A tale-sternth perreemrrlrirrrrr [Pei erreleeee ire cartilage externaer Pleerrierehie cmnrlreerfiee [l3] 'l‘r'l’th email. dar'rr nuelei eeeupir lacunae anrl are regularly errangeu threuuliuul the mailer {till} Because ei cell shrinkage. lacunae entree: as Clear SDBCES areunri each chendreeyte. The matrix Fee a lierilar ahheeranee and consists at a irehrerlr eF eleern: fibers that ere Clark eelet eeceuse rrt eelecli're Staining rrir reserein-luctrrru'r. EGG-x. Weaver-.112“ r3.-.'r. hart-ear Lest red. 1' Lil! at elastic cartilage in the adult epinlattie. The semi-en paeees through the perizl'ehdriunt [Pe‘r matte rneetl'y of regularly arranged mile gen there that stain green 'Ihe black elastic fit-er bundles H in the matrix of mie cartilage term wherle aruune the IflClll'I‘fiB. L‘afllCll lifitl$fi eltnrltilneirterr, [8}. 32m. l-S'trl HER“ Unirti‘n'l. 1. Higher magnificatinn Ln! tit elaetit.‘ m'lage sheeting the arrangement at elastic fibers in the matrix. The elastic litJEre rare eraek 690A. ten {rare-r green-r ' "at. m! .1..,...'-r- El Eleeuier. Ovalle Bl Nahirhee: Netter’s Eseential Histrcrlhgrgr — www.5tudmtconeultmem 1 Elam niurrrgraplr {EI'IIJ III In hum mat in mm car-Ellyn. Eariirage mair'rr smrmnfls a pair nichnndrc-nllltea Each cell In; a single nudeus {Hui and an irregular cell bard-er wilh shun. 311m foot-like mansions [mum] {If nimrna rn Emit-rare. Tile crrmm has air-Julian: HER wiilr [iii-1h imam and dilated {-4. nisternae. Surrwnring maximum matrix has a finely fillile appearame. 35,3301 rim-mom. H .r. Gram-ml II- Ell III a marina-flu in Main rlilananf ma um. Tire amt-Firmly prawn nucleus {Hui has mnrmnarln and patches fll helemclrrnmalin and is surruuntlrxl by a well-willed rimimr warm. The tfiflllh‘ifim is [We 'i'IiIEI'l orgamiles inquired in simmis and mefinn. Hill and a 'rI'rI'IEI” dues-Iainan Gdgi mrriplmr {GB} are prmnirrmr. The HER comm ni parallel arrays ci' narrtrw cisternae slim-19d Ir'rilzl'r rims. Miinmuiflr'ra [I'll Iii: summer] amung HINIJEH‘IIS Elf 1MB HER TllE Suriflul'lllil'ig rrirairirr conlairs a mam-rut of type II collagen fibrils. GfiIfile. Emmi-r [II Dr. B. J rim-«mm {El EISEVler. (ii-ladle El Hammer: Fri-Etta”: Esaentim Histology ‘ www.mda'ltmnsultxum 1 Skeleton el' tel-term mums er hinh, skeletal sesitieelien centers are rhestte erirnen.r teeters: seeehtlere centers are feunrj in the distal lemur. prestmel tileie. and heart ef the humerus. Merry men-dent senters ate net term unt'rl e number ef years after birth. 1 LM ef the heart at the developing humerus at terrr magnification. The eeetien eessee threueh the epiphssis {Em and pert ef the diameters [Di]: of this Ieng hens. first-eh in tength et the teens depends en the eeipheseel grewth piste tfiF}. which is the tests Ier endeehenerel hens fermslien. 10s. reeasm seems. [E Else'rrter‘. Desire Er htehirnee: Elena‘s Essentlet Htietemr — www.studentr:ensuit.cem 1" Woman: In atmosth {Haunrshn 1" Initial Minimum in mesencnyme. W} "m" “'“lm'mm” “'3 “3 Wm- Mesenchymal cells surrounded by matrix Dsteeblasls line marrow space cal" pn' m art.- dstren n5 Capiliary Dsleopregenitor celts mlmblasts irern mmnchymal cells send out processes Collagen lib-em laid duwn as organic matrix tasteuici] Collagen fibers impregnated /with hydruxyamtite crystals [a farm mineralized bone matrix I COHCIE'HUIC Iamallae flatmates in lacunae of developing lfrem asleeblasls} secondary asleen I‘lmrer'sian canal :tn' semrldartr ostesm with 6 concentric iamellae Osleocyle processes in cnrialicuii 1*mymnwifllfimnmtficlam Eariy Stages of Flat none Formation n.4,»... -u.-.-.-. .-.--u «M- wens-J --«-\..'.1.--.-: -m-,‘..-_ Trabeculae lined by osteohlnsts “mm-fin canal lined .-.r. .. _ . . . . . and}! TI; ' . ' .- " ;- ' Capillaries Il'l rrlarrcmI spaces in" 0' ESE ._ I in...“ _. a -. . - ht"? / " - .. 45-. _ ._ , __ Dense layer ofsubperiosteaf . bone surrounds primary -Pmmm'm trabenular tunne- ol nitride-159d Ca .“ ..b d .Wnchylne pl dry, nerve Tl er an asteupmgnnitur cells in Mar-m 5135.395 HEWEI'Si-fl I'I canal -I (primary 05mm} flstflyw Pr within canalimli Bony trabeculae lined with meridians E: Elsevier. mile 31 Hahlrner: Hatters Essential Hlflifllflgf - www.mdattmnwltcnm T monummmmummmmmm}. Hyaline cartilage r ‘35-?“ Foriosleal bud " remaining capillaries, Hypenruphic mefiflflflhymal cells. . . . d osteoprogenilor calmly-mg cartilage 3" in wimw oells passes- 1I1 rough ossification center how any in Flarichonda'iom made ciapl'tys-is. ‘ ' " ‘ 333’ Thin loonyr collar Seconan ossification one-mats for head and groatw tubercle Bum d Pm’dml epiphfiis Calcilying cartilage Adioulm cartilage Sieii:-::ini1:lr;.r ossification ' ' center in Epiphysis Pro ' ml '3- Epiphtgaat Proximal metaphysis = ; graiin plate Duterpon ol perinatal _. ‘ bflflfl' beginning to tra nylonn 2?: inlo compact bone '. _' DiapII-ysis growth in width Lg; : was ma W], oocurs_by pedosteal bone 1-}: ' of long bone mmatm” .353 Modillary tmatrmo] coo-it}- Dotal epi physeal girth plate Distal metaphysis tlfl‘ Anioular cartilage EFthfiEfll capillary.- _ EL .lfii . a '5; E: Elsovler. mule El Hahlrneir: Hotla‘s Emontlal Hlstzolognir - www.5tuda1tconwlt.com .rir- "vs-*1. I-c- -+' 1:" =1. Artii‘ttlar t‘nrtilt‘t e . a f Uri-lose _ a _, t I :i . -. . I ifs _ .-;_- refitflfls. ,_ lat-5L Sectintlawossthcahtin canter I I . ifs. » (.titlriorfcnrnlope -o a Si} w Epiphyseal ttrle-r',r Rm“, Reset-cur.- 2cm e. Pmlii'st ratio-e (tine Emir- (if r'natumtinn and its-lmr‘rrnplsp done of prc-uismnaf calcification Znnc: cil' ossification II. MEL. r '_ tpf'rpsis II‘ gay . _r I. *5 .j_ I! Iflflr Ir. i .ll . _ ' I It" ’i'tl “new I'lll- t'ii'tetapft'gi'seal Elmer}- hf.“ ED .‘JG Jame. s:- t- " _. st} ‘- .s .5:- I F #1,... «NI-*1 r '. o n a; l ."'~u|l.l1l'il:"l1I .‘l “Eli—'7'?“ 1. Semantic of the growth plate showing shuohtre and blood amply. The two proonh plates in a typical long hone are peripheral extensions of the primary ossification It Low-nugnificaflon Hit of the growth plate i1 longitudhal section. The center. The primary center grows and expands centrifugallyr proliferatfire zone {PI} shows closely packed stacks of flattened chonclrccytes. zones of in ail dirECIlEIl'iS Ul‘ltit il hecornes confined ID the DUNE entls. maturation and f'lil'tilt?1'tl’t‘li'JI'l'f.r [EH] contain enlarged cells. which create Sl'l'lail ClflEl'i cavities a protein plate consists mostly of a caniiapenous portion in the provisional calcification {Pct zone. The cartilage matrix becomes more oasophilic as with various histolopic zones anti 3 hon;r component known it calcifies and gives rise to slenoer spicules ferrous] of the zone of ossification {20} that as me mEfflDhfifS. project into the manor-t cavity. 150x.t1'tipfrt's. E) Elsevier. Goalie BL Hahirnev: Nefla‘s Essential Hifitfllfigf — www.studeni:consult.corh if!“ "' Slmtiural and funciinnal Em'lh Plate Inna! changes in (hndrgwle-s ." .-.. c f'r' F—"' iH-Ir i!" ii 1"" '1. ' 1 ' '.'r "11:53.1 -35 Matrix Hfldiifliflli lit‘wh'i: mnr i'i'ul il'nafivi: mew 1: ll: quliirili'i-i ., - - frallrlaf - - “ _ w rlMliiralimlaIHI .. .. - F - .- huxfirmiliy , - .. .I'iri'uliiuLtiini'in iii iil‘li'i'l. . g _ in-mgul. alkaline gilileiilih‘rtflw; ii'litlriii. " - '3' :‘.ili'iiu'.i|iii|l L 'L_-'_'.J- r; __,_-'.;r-' -, Inririnl' ' w" " 'léfid—a '- "I ' L imuiiinrlnl r.r|i 'i iii '.IlLii Ill .- H35 2: 1.- '- fmie rii' mrici I ii'aiiuil - l’nllmrg.‘ “mnflim Mina pin-aim; - Sit-minder)- spur mine-a ii. mmmnmmmmhmmml aecfion. Oman-miles mi. arranged in culurrns. grugreaaiirelg enlarge iirgm tie in ringing] and lea-lie emglg wee {e} il mlniiierl malrix. The memim'ifi'fi and mm: nf riesifimlian are in 1hr: Iriwrnr rigl'ii. Sfflx. ii‘iF. «I Higi'i-magnilieelim Llil of pm 0! iii: matang in em bone inrrneiinn. Newly leirried. unmnelal'eed aalerjrl ill!) imrr'iii a lill‘l layer on surfaces at calcified cartilage air-mica [BEI- Tlie esteem malaina email gaiaflasts. The mien-sag stained HHHJIES wil eieriluallg he resumed [lg nelexlaeg; incl}. The large limiiiiiucieeied miemlasrs sir iii ream-lien imifles— Hamlin lacunae- an the naiegid. Email elmgaled cells in aurrgund-ng areas are gateogeiiii: cells 109,]. Elli-c. Wife '5. El Elmira. malie Bi liiahirneii: lie-11ers Essential illicit-gr; — www.5tudmtcun5uit.:nm Ir Llil ei‘ mam epmgp bane showing part of a bony trehenils. The intensely epsinppnilie trahemls is made pt Ismeller hene {LB}. Ernhetteee in the Deny matrix are petepeytes terrain-e} anti their Iaeunae. which are small and spintIIe shaped Flattened eells en the traheeplar surfeee make up the delicate endesteurn Eli] and appear te he Inactive. Sprreunpihg hene metre-ii {Bill} mhtsins abundant small hemsteppietie Dells anti measieeal fat cells {FE}. Because er the high mineial eentent anti harmless ethane. epihenpenal histelepir: prepeietipns require deseleilieatipn. whereby sheefien of calcium permits tissue sectioning and staining. 2405: use «1 LM of fetal bane showing a deheipping hnnpI heheeule indemnity bone deneeltim and resorption. Deteehlaste tflhi engage in active hene Formation and term s mmetaper pt plump. euheidsl eehs en the traheeplar suilaee Unmune ralizeti estepitl will is the thin. pale lay-er hep-teen these cells anti the mere deeeh' eteinezl matrix ef whiten hene MB). flstesttes If! we waver: Dene are large. reune tells wnhin elear Imnee [HEM]. A large. multinudeeted esteeslest {Edi ha in entither part at the trehemle. Surreahding lapse DEII'II'tECff'i'iE tissue :01] is higthp vascular and ounteins many thin-sashes hip-ad HESSEIS thin anti mesenemmsl stem cells. some at which will bemme esteepregeniter Delis. Cells hi the end-esteem tEnl. Ilit-hieh include psteagenie eelre anti inactive esteeplasts are en the tease: surface ei the treheepls. Emir. HIE. El Eleevier. fleeile Bi lilehirnep: Netter‘s Essential Histcilemlr — www.5tudmtmn5ult.cem ...
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This note was uploaded on 01/04/2012 for the course ANT 511 taught by Professor Thomas during the Spring '10 term at Philadelphia College of Osteopathic Medicine.

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Lecture 6a - Imam. Mimrnr cartil. Sponge {trabccuian bane-...

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