Lecture 6b - [Mm IILI Illl1|1|il1£fh1|l£ll1l111xllfifil...

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Unformatted text preview: [Mm IILI Illl1|1|il1£fh1|l£ll1l111xllfifil -- :Li‘l “Hectic-I15. rraljfirculnemm . .:_ . _ _ appear as. (In.ch ntlnucius epic Lula-i Ann-E- {meat-lam produce DfiEOId Endnstc-Ilm Iirl‘Jlilli'l" lhll'I'II‘JI.'I\T"h and cJ$r4:c)-prL-gt-I1iltlr trelli- Marrcrw span-5 finniialn I‘iI-lrflflT‘tiji'UH-‘llllii EJHIIH :1I'I'EI fall [NE-:Jrlnsh in | Inn-tins: inruniw IFHIZJE'CZLII 3H A: 1 iw n-cre-nhlairs - L‘ . - . .. _. | m]: nah-urn irrnc1iw4h11|nhl HI» + .‘5‘ _ 1'_..._ I. I Scclmn nf lrah-Hula ii: .I ., : ._._ _ .- and Elstmpmgemmrmm QR" %- - .i Gaelic-rites in Faculme and canaliculi 051ml: last in Hc-wship- lacuna Ir LM afpairtnfa banytrahacula inleul spongy borne. In this Manning Irahccuia. a row of namhilic cctenmasts mm is on one surface. viri'rh cstacict [stainec iighteri immed satay below; Mn cam-masts incl] in Hangman lacunae are cm ancincr surface. Daren-mes ins] in lacunae are in the tinny matrix in!) its intense ensimphilia is clue to me presence of typcl milagen. Eurrcuncing cunnaclnre unsuc- {ETi ccnnains undifiermhated stern calla Including aslewrogenitnr cells 533K. WE. El EIBE'IFIEI‘. mane Bi Nahlrney: Hatters Essential Himalcigyr — www.5tudmtccmsult.cnrn Elana ma n‘Uw contains han'lampai as i: calls. flutes circul'nfsarenlial Inmallaa * :_' fa: cells. and sin-.muis I _ L lrabssculae FIIDJECT inn: Infantitia! lampllne ' " _ , central: I'I‘IE'IIIJIIEFy' _ .- ' lmarmwl anvil-y Capillary In Has-remian finial :'I . ' - ~ CHPHHW i" W'kman" “"5” = ' Paripharal anariplar blanch *- - ' - pl” nmrianl arts-«y gist-s Emim .win _1- _ _' _ ' use a: capillanas fhal r} - _;__ 3- arr-tar 's'ullu'uann canals .- I. : . I pl mil-act hunt-r Nutrient artery passes inlp --.-u _ «' " “if; I rI-urrisnt [Hansen p-Fdlaphysis ' E - - .- -- _ ' '.'."' ; .-.' . _,l'-" _ ._ I I - I I. :_ ,:._.I_ . if. ifilrnm III I - I _- '- '-::. I - _-__':.' _ _ ' - .. —__ "' __— :L.‘ . ' f Inna-r Circumfiaramial Iamallae -' . : r - ' . - : ' :- CUHCEIIII'HIZ larnEllaE - I 593 " “II , _ . I I“ X. Fil- pf lasts-0n lHawsIsia-n systsrnl L!" I'- Gml'lll ans-11pm bans in tram sssfim. In this unstained. ur‘slssalsifisd prsparslim. sans has been dried and ground dawn with atlasiu'ss. This ass: man reveals the arsmscass ans rnina’al [margarita mpsnant sl Dans but sass not Drsssnls sans or srpan'rs mamas Eash Is! the ssssral Harsrs'an systsms manalns a casual Havsrslan canal {Hal Tnssa canals. small spindla- shapes lassnas. and slander panalim'li appear mad-c. 1ll'allnmann canals {HG} run sauna-sly wlmin 111a m'naralizss mania. Tfix. 4 LIII nipaltulanuallun andhhmliliallams-llasina nmflmfisnnf compact bans. A Hamslsn sanal {HE} samples the mamas of an amass. flanaliculu [Ea]: form an sstsnsiss nah-ma sf slsnda' tunnels Ihat ssnnsst splay-Ilka lacunae {La}. Lasunaa and sanaliculi appear black. 525x. 1E: Elsa-slat: malls El Hahlrnes: Hatters Essential I-llsl:s.~lss;r.nr ~ www.mlzlantcsnsuitcum «1 Ltd of doealsiliod diaphrais at a long bone In longitudinal section. The outer cortex is made at dense contrast hone [GE]. |rrrhereas trahecuiae o1 spongy time {EB} protrude intolhs hone manor-r [EH] saute. Compact hone appears as a solid mass: spongy hone slur-res a network at platelike lraheoulae {errata-s} hindering spaoes occupied he riot-lg.I cellular hone marrow. Fan ot lite penceteum [Pat at the lelt. is separated by an artilactual space [rent the outer hone surface. 1 oox. Hes. II- LII of decaloifled colnpaethoneat higher magnification. Each oi three adjaoent osteons. shonn in transverse section. consists of several lamellae concentrically arranged around a circular Hairersian canal {HG}. Each canal Is a conduit tor a capillary tflani. Although not apparent here. ooilagen fibers 1.rrriti'r'rn each Larnella are parallel to me another and pursue a helical course. whereas filters in adjacent lemellae are oriented at right angles. tineoones (Us:- in their lacunae are arranged circumierentialry around each Heserstan canal. Thin. lightly haerphilic cement lines {GL1 are seen at edges oi the osteons. Canaliculi {0a} connecl adjacem lacunae. Their appear as fine striations wiltrin the hmy matrix [see the stnaIi encircled areai. 240x. Hgfif. En Elsevler. mane a htahlrnee: Hetier‘s Essential l-tlslasincltrr a www.mdel'ltconsult.com Schematic semen df tie-calcified bane elm-s- .tllnt'l'lrnenl at FJ-Pl'ltllilfi'lllll It; Iii-sine be penetrating [Shh my] fibers III'II'III'II' IJTE'I {mtfiflllflfitfl i“ lacuna 1" or as it LliIt showing the periestetln en the alleles at a hens {deealeilieth him an elderly parent. the DUIEf sates. ts the right. CCH'llait'is mare elaser passed esteens and Hesersian eanats [H I3]. the hang; matrix is intenser eesirenhilie heeause el the high eeliagen enntent. The eeriesteunt {Fe} eensists el en miter filareus laser with densel].r dashed eallagen fihers- Its inner saifaee eentains sells that vary in mmahelegy depending an age and functional state. Here. hens gretdh is mmalete. and these sells are lihrehlasts that seem inastlse. Surreundini; eenneetise tissue. In the left. sheets seserai neurasaseular simetures—arterieles [A]. ten ules M. and a small nertre laseiele [H]. lEIfitx. Has. [it Elsevler. Dealle El l-lahirnee: Wetter: Essential Hifidldgtir - www.5tudattednsult.:dm T Bullagm synfl'lasis Fibmhlast, chandmcsits, cir cistscihiast Cell membrane Hi} Prcuccillagcn released into axtlacallulal space by cancytcisis _ _._...._._ I {31 l-tytirciaylalion culprit-ler and Iysyl aminci acid rasiducs begins as pic-pm- alprha chains enter cistern. Rflpiiit‘s vitamin C. FE}, 0;. :2 ,. . i: i: . -I :- ,. i2] Giacolsylalian by enzymatic aciditcin cir' galactcisa tci cantain hfllrcaylysina residues . '33s" .‘a‘h‘a'l {Icillagc-n + .. . " - u . _. . I n .. . I. 1 . ‘ . 1 . . l _ .. .. . . .' . .. . ' . . n . ' a .. ' I 1 . _ . r I.- .- .d . . I 1 .- . r I . . r r a 1" I . . I- 1 r. *4 . :. .. . I: ._ I. n I- .' I' r: f: .. a .I: : I 1 III F F + I + 43's". I i. li-i-I+-t -I. -_.-_-.‘_|.-J|.-_|. .I. p! I ! i5} Icrrnirral peptide-s split off by liraccillagan : pantidasa . 'u‘ I-Il'I-a-Ii-Il 'i-Ii ". tr." its] .i'l.ssa=_-n'li.iljrr intcr fibrils [quansr staggarad} with 5-: -- t1i3 praalpha chains assemble “055 link" El _ intc': triple halix " I " " I» EM Ill type I sallaum fiuils at “El hm-Iidml his Cit-l groupi- x magnification. Crassasanding patterns (E i/ a result at staggered alignment of traps- sallagea malscuiss in finals are visliils. Hula canes {mm} batman adjacent molecules prawns sites for dalmatian sf rrydraayapatita mistals as minaalizatim begins. WEDGEIK. micsrtfifl. l. aisartsiir'ii Each alpha chain is made- at ahcul 100i] aminci acids. [vary third amino acid in chain is glycine. smallest of amino acids. Glycine has no siclc chains. which permits tight cclil. ii and ‘t' indicate other amim acids iii alts-n pristine; ti cits" hydraaypmlins]. Pic-tins arid hydroayprcrlins, radiactiuciy, ccrnstituts about 26% and fifth of total amino acids in each chain. c: Elsa-vie: (testis a Mahirneii: Nathan‘s Emails! I-ilstalaai' - www.mdaitcnnaiitcum «II 1* Elle at pants at active eatenbtaate adjacent I: eatenitl. At low magnification: (bath, the cub-ales! cell eentaine many titiitnzlglI packet! arteplaamia erganellee. which is Censiewnl Iwith a tell: in cetetid eyethesie anti aeeream. he euchmnetia nmfleua {Hui area-la a ataninent nuclen‘ua {n}. {latte-plasma: ereeeaaee iatrmaa ef the eateahlaet extend into surrounding eeleaid. An irregular errantl of type | eallagen fibrils emuaiee the meek. which is net yet nineralizecl at higher magnificatinn (Emil. the neoplasm indudee men; prefilee at BER and mttnehehdna {ch The nucleus contains light eudiremattn. darker clumps at hetereahrernelin. anti a uranium-ht nuateti-iue [w]. The matrix Shaw's. collagen fihrile. Left: amen; Battier: 210mg. r .- - '. 7!"...- -..- ' a a.- .-" "-.- .- '.o J E) Elm-tier. matte Bi titahirnee: Nether: Essential weakening“:r — ww.studmtcflnsuit.mm 1| LII ufhmu. m {III} II man an; sunmmu Dy um: rrtalnu. Emma urmmms ma 10:1meme mdwmmm anal-3m rmmdn: flasxmflsecnmfimgemunnmmw madam is an Mammal 1m m matrix. x :35 l. Elsdaaim mm mm ImaJHu-‘mmmicatmnm. mm in its mum is mwmmmmimmmmcmmm:mmmmnm.mmmm rma mm mm Lil}. mmmw am 3471mm: mama-m mum-15m: limes mm memfiom ma nae-H any. Hmr WWI M mans a mamlalmmmlt Incmmm mm gingham: mm. 1mmIsharmWalmwfllmmmun.EMrmwwlmmmma Miriam. Laitmflflxmiglfl'fljflflx. 4:: Elsevla‘. Mia 31 Mahlrnev: Hetlaa‘s Essentlal Hlstflhgf u www.5tuda1tcanmlt.cum T LII bf lama shinning t'era aslsaslasts {flu} an lbs surface D1 bane. THESE large mulaneeleated sells barre milled barriers bn lire side faeing me baby meirirr. A resargiien sarigr is indicated iii. Stills. Hes. .~.—_' FIT-'lalfl‘h: :. J ‘ ' a. EM of an astaadmt in the grasses sf resenting bans. This large cell eantains many miieenanbria. lysesa mas. and resieies ei rariaus sizes. and several nueiei {Ha}. Iis eeii membrane has an irregular aniline. wilh a are mine-m ruffled barrier iarraws} in eaniael 1rriil‘r bane mm is being resented [a] in Harrsnig lacuna. Parts ei ibe bang matrix under the barrier are undergaing demineralieetibn and disselutian. 33mm ramnesaarbr Hi. L Him-reg Ell Else'rier. Deraile- Er Hahirney: Hatter“: Essential Himalragar — www.5tudentmnsuitnmm Disrupted peritoneum Chat in fracture defect Proliferation of osteoprogenitor cells of pariocteum Haoersiari canal and vessel Laco nae in compact hone Usteoprogenr'toi cella of endosteurn lining Hamers'ian canals- anr‘l marrow cavity Bane fragment; Section above I - kMarrow CEWiW Fracture across shaft of long bone 1 Bone malr {ear-t1.r place}. After an Initial inflammath - respmaer the catty repair stages inrolrie profiterafion of “W toleoorooenttor cells of the oefioctaim and encltcleurn linlng of Hareraan canals and marrow cavity. These cells differentiate into cnonoroolaatc. which form cartflagemoa callua and coteotIaets. which produce new bone. flotaodaots reooti oeeo Done and hone fragments. The oariooteal reaction BHIBHEIB beyond the local frazture s'rte. {El Elaevter. matte Er Hahirneo: Hetlaer‘a Essential Hlstaalonci-ir - www.moo'itconsult.com Bone Repair {Intermediate Phase} Flbmus perinelwm Coming external callus External l‘sartiiagenuus mllus [firmed by :hmdrnblasls ' 1MylIlIslilzrrnlgeniv: Lunar 0f pedesteurrl New bone and meepmgentter cells m” enamel callus replacng cartilage Bone Repair (tale Phase} I: let in fracture (Select Fibrous perieslmm NEW hens: and neteepmgeuitel cells or internal callus bridging {rectum site I eegenic layer of periesteurn New mum-en bone in esreml callus Residual islands ni cartilage in man hunra Mineraliaefien nine-w bane with fennatien or esteens Wells-en bans,- in internal cal lus External callus lnlemal callus Mil-CW I. Externalealheeihme weerlflgeiefumeflhyeemogeaflu‘ who! file perineum. Bella form here in areas of Hugh Il'atlazlslariljl and mm manage in arms 01 law mummy. As new eapilarles mew. raw none replaces eartiagennua nellua. I'm-rial nine is formed tar eeteapragenitu {lfl'ilfi Of EDUCEWJI'I'E and E prlmariy l‘l-E‘I'l' DUE DEEELEE D1 hlgh merger] m“. L wwwflexh'nel Mummumnmm lame at him eeflue and bridge lhl flefeeljene is madman leeflaeta resort: callus. Ema-arm: layers or iilfil'llE! la‘ui awn amend bleed male farm new Haveeian carela. 4E: Elsevla‘. mane El Hahlrnev: Hatters Essentlal Hlsl:1:.~lrlu;|l_lr ‘ www.mdel'ltcenwlt.cem It Law-magnflieafiun Llil afaral imee iii-I'm. maeuiating ends at the tram are BEBE-1mm bit a ethereal cavity. 53:. nae It l'tledium-magnifieafim LII! at part at a rat lutaa jointfirijeulating ends often] belles ate ewerett hr fll’TiEUIEI hyal'ute caniiage that. A triangular meniscus inlet pmieeta Into the seneuial cavity {at Highiy retitled atrnetllunt :33] lines the inner austaee ef the fihreua enter capsule [0G1 a! the leirrt. Ffix e35. «II High-magnifieatian Llil showing details at a emu-aim villas and the synmrium. Synwlccyrtes Eaten-a} term the intimal tanmtal lining. The senintimal layer it; highly.- uaeeuiaatzed Fume cmnectit'e tissue {GT}. The villus. ptcjecte late the ayneuial Eflvl'iy it}. Fans at the ITEMSEUE [He] and artteutar eartilage Wt 313 shaman. 505x. HE. E) Elmier. matte Bi Hahirrtev: Net-hers Eseential Histoicrg'y' — ammstudentmnsuitxem 1' Stmchrra at lire synaviurn. Fibre-us swmium I. EM at filrruue evnuviun. Part at a type A {A} and several tvpe B [B] avndvincvtee make up this area at the evndvium. Underiving matn'tt ccneiste cl collagen fibrils eecticned transverser {its} and longitudinally {la}. The evncvial cavitv {4 ie ehcvvn. acme. swovi urn Sumerium :- E _n F. I?! -. cartl age 1 SchematlcEMsc typeMlefllandtvpeB {riaflli cells or fire evncvimu. TvpeA cell has ntaneruue Ivseeemee tar phagdcfleeia: Wile B cell, abundant mugh enddnlaemic reticulum fer eecretidn. En Eleevler. malice a Mahirnev: Hetlaer‘e Essential Hletclagv ‘ www.ctuderttmnwlt.cam ...
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This note was uploaded on 01/04/2012 for the course ANT 511 taught by Professor Thomas during the Spring '10 term at Philadelphia College of Osteopathic Medicine.

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Lecture 6b - [Mm IILI Illl1|1|il1£fh1|l£ll1l111xllfifil...

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