Lecture 9b - «I Llil ot' a lymphoid nodule in the paletlne...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 8
Background image of page 9
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: «I Llil ot' a lymphoid nodule in the paletlne tonsil. Linde' the stratified souamous epithelium iEpl that covers the tonsil surface is a profusion of dark-staining. closely packed lymphocytes. a spherical lymphoid nodule lull) in the lamina propria is capped eatanaily by a mantle zone at similar lym phocytes torrents]. The germinal center of this nodule is not soon Tonsillar nodules also contain many macrophages inlet. I-rnoirm as tingihle {or staJrLahle] macrdmagfi. Their presence am one the smaller. darker lymphocytes produces a unicpJe “starry night" pattern in the nodule, 1rli'uch Is a desert distinguishing results of this tonsil These macrophages phagocytose deyeloping B lymphocytes in the nodule that are either apopiotic or undergoing degeneration lode. self I- LIIit of a muoous gland in the palatine tonsil. Litre clusters of grapes attached to stems, groups of secretory cells oi the mucous grand [H51 organised as acini. are connected to a branched excretory duct l-i. Epithelium lines this duct. The secreiory cells appear washed out because at a preseason artifact. Surrounding connectiye tissue stroma [Elli contains loosely arranged IymptioCytes ano plasma oells. Although the foil excretory duct is not seen in this section. it conveys mucus to the epithelial suriace ol the tonsil. This secretion normally cleanses the crypts and keeps them free ol bacteria and cell debris. trifle. oar. Ell Elserirler. Dyalle Er Nahirney: Plotters Essential Histology — www.5tudmtconsult.r:dm {Atmrrant flarnthemitl gland l|l [Pharvngeal fistula l’nralllvmid gla nrl I'v' Ultimabranchial bath; Pyramidal and Iateval ventral WI “I [lube-s ul' thyrciitl gland Paralh mid land "1 3'1, Pha'WEW-I M [Pmistint “Ed fll Ihv ill-Ii {Pharmacist iisrluin. Nterrantparathvrcid gland III h -- 3rd waml m [Thymus gland 1. Ltd at part at a mild's thymus. a thin cuter capsule {Ba} sends thin 1 us at part at an adurl'. thymus shearing partial Invalutiun. edipese connective tissue trabeculae tTr‘i into the Int-e tn fprrn Ieeules. Each Iceule connective tissue tflTj. made mostly at [at cells. praucminates at Ihis stage {fine i5 Bncil'clfildl has 3 dam'stfliniffl flfll‘iflhflrfll WHEN [B0] and 3 Fall} because at a gradual less at lvrnph ecvtes with age. Remnants df lymphoid staining central medulla {Ha}. lviedullarv areas at adjacent In puies nften perenchvrna teirciei have a round is irregular shape. Thev may.I captain leplt cenlluent. Bleed vessels {Bil} travel in trataeculae is the prgan's areas at certain: and medulla, but the hpund arv hetuveen these areas inIEFiEIF- Unlike Either lvmflli Did are EWS- “’13 lhvmufi Uauallv lacks midfield becomes indistinct. Bleed vessels {Bil} ate preminent in the ca nnective nddules. 42. sea tissue cf the invaluting thymus. 4x. Has. {El Elsevier. Dvalle Bi Mahlrnev: Niel-tar“: Essential Histaliagv — www.5tudarttccmsult.cam -Il Lllil ol part of a child's thymus. h oelreste conneoo-re tissue seosuie [at the tool senos In thin trseeeulse [arrowsi to form irreoolor loholes. three oi which are seen here. Lymphocytes are more densely Dooltecl in the series lfloi than in the medulla Met. The alone of section rletetmihes the oooeotance oi the lightly steinetl regions of rose oils: either closet] eorhoertments surrounded hit cortex or a continent central region continuous hen-teen looules. The medulla comshe loosely.I sacked lymphocytes and many Hassolls corpuscles th‘h. which are recognizable st U153 magnification. 55:. roar. II- LIII of part ot the cortex of a ohiltl's thymus at high magnification. than;r closely hachetl lymphocytes [Lei 'r'llEtI'l srhsll. romio. henser stained nude; orettornlnete Eollhellsl reticular oe1ls tEFtIDl have large. round euchromatir: hostel. with ororninent nucleoli. Their cytoplasm is eosinoohilic Processes of these cells tarrowsi sensor to inlrest capillaries inept. roam.r o! which are seen in transverse section. This pattern in the cortex constitutes the blood-thymus harrrer. which limits assess of blood-home antigens to immature tern phoneme. 320st. rer. Ell Elsevier. fissile Ell Nahirneir: Mother‘s Essential Histc'lllcrgrirr — Il-rt-rtrr.s‘turzllenizcrzrnsl.tlt.t:t:tm «I Electors mierug‘aplflEflMlfltamflattuiflnthynuraAn " 3- .- _ - - -- epithelial reticular cell has a large eudtrcmalic nucleus with setreral _ i Emma}? -" t - ‘ :_ ._ - nucleoli. called a thyme: nurse cell in this area at the thymus. smich mmtifl '_ _ : _ _.-l - ' - is directly under the sapmle. it is diesels associated with small. - ' ' "f; i tightly packed lymphocytes tlyi that are maturing. httnuugh nct t-reil at thiS Triflg‘tififlfltiilt‘l. the EDithEI'EI i'EtillulaT Dell cytoplasm contains abundant tanatilaments. tQJtt'iuz. h- Eh'l showing Iteyr techies at the Island-thymus barrier it the deltas. Capillary endalttelial cells in this area are usuallyI linlted as desmcecmes icicle]. A thick basement membrane lBH} eurrcunde the endhtl‘telium and alsd invests the thin cytoplasmic arses-sees {am} at adjacent epithelial reticular cells. Part at a macruuhage seen is recognizable as the numercus issuscmes ll}. 1?.?UU:2:_ Kc“ Else‘rier. matte Er litahirne : Hetter‘s Essential Hist-std — www.mudentccihsuitxam w .' ':" :1 'l ,r' : ,_ t . ' i I w k - J. . _ I .. . _ .. L l.M ot'part ol‘ the medulla of a child s thymus. ,_ 1 it ‘- _ - - - _ _- F _ i __ - _ ' ' Eosinophrlic Hassall's corpuscles {HE} are in yiew.‘ " - - .- " ' - their sizes yaty {EU-15ft pm]. Some show concentric epithelial reticular cells and others. hyalinization or degeneration. Capillaries {flap} are seen among the lymphocytes {Ly}. 31th:. HaE. : _ ,i l Ir- th ot Hassall's corpuscie at higher magni- fication. This spherical body is characteristic oi the thymus and is unique to the medulla. Its central area of degenerated or necrotic cells is surrounded by flattened or polygonal cells. around the corpuscle are epithelial reticular cells {EBB} and lymphocytes {Ly}. F5flx. HSE. In". m".—--.b LEI Eleevier. Goalie El. Hahirney: Netten‘s Essential Hiiology — www.5tudmtconwlt.com Diaphragmatic surface '- Ce'rttri Lrlt- ' - .1 ' - In: | I. I J _ -r g. .I‘ .-' - -iI I I Spit-at i r. 2 'J" trt'LLt-E't'u lae Spleen in situ __ .' _ _- Cross section: l ' 1 I I- Lan them either aplaanatinw nugnit‘ieatinn. a thin capsule [cal Invests the prgan externaliy'. The substance at the spleen sansists at small rpand islands pf lahite pulp rarer. up ta 1 rpm in diameter. that are embedded in red pulp lliPl. White pulp is made at eernpaet lirrnphbid tissue that terms splindrlbal surfs arbund the branching neti-rbrlt at central arteries in the organ. The mere abundant red pulp makes up the bull-t at the spleen and has a relatively IEIUW persistence. All elements at peripheral bleed inllltrate the red pulp. Trabeeulae {arrows} are indicated. HELP. J:- . I . -' I i I I! .- re Elsetrier. flea-tie a Hahirae : Hatter‘s Ementtal Hlste - - - www.stUdeItteensutt.eem I. an-magnil'icaticrn thl at part at the spleen. The capsule gives rise hit a trahecule lTrl. Dark-staining islands pf lrlt'nlte pulp are emhefictecl in red pulp. 413x. tell? 1' lllE cf white pulp. hrpuncl a central arteriole [Bill is a cut! cl lymph ccytes—a periarten ctar lymphatic sheath tPilLSi. hesspated path the PALS are a seccnclaly lymphoid nelille [Lilli anti its germinal center [Em lflutsitle the thin marginal eerie inflows] is led pulp. Splerllc lymphoid nodules are Iisrnercus ul ypurtg people but hecplne relatively scarce with aging 13px h- Llll n’f lhe capsule oi the spleen and underlying rail pulp. The capsute ccn5isls ct cellapec enct elastic fitters Irrith scattered Ilhrchlasts and a few smc-ath muscle cells. Hie fihraus capsule is usually cayerecl by a serene mesclhelial lays: at the ciscercl periicneurn inst seen here}. which is nprmally simple spuampus epithelium. the reel Dull] ppnsu'tutes Tfi‘t'u cf the Irelunte ct rhe spleen anti ccnlains all lcrrnecl elements at circulating hlac-d. Vensz einuspitts are not seen at this mwniticaticn. 290x nee. El Elseuier. (Nails Bl hiahirne'y': Net-hers Essential Histology — www.5tudentconsult.l:em Clip-en Eirflulaflm {lose-d CilCU1fl‘IIIZII'I: Central Merioles SIIL-alzl1eefcal‘J-i1laries PAB- 1 [ll nimupiean almwhgtmlh and red pulp after Injac'llun ul' hula Ink. Macrophages are alien dll'lizull tn discern 'n msrrllenal - nlslmgi: SBfiinE. Illemlnn cf hula lull: lme an eepenrnamalanlmal. lament..- ml renmal 01 the spleen and 1m“ lls mlcrsamnl: mamm. allews learzlim Dlfldllfll in Mlepllages Is be seen. lilals see-Mae prep-aFetl fillfl'l'fsa llighuxwmatiun m Emuluphaglss 'ntl'le inarg‘nl acme Ll white I pulp alter eells ingested mace mm [Jart'lcmflf ink. Ulnar areas el we Swim. mm Tgfiifia’ mpsaenalea malallerisle [mmnmissmameedmlmaama win- ' "— h-r‘rfl'm Mauls lull. Fflx. see .I Bleed simiaflm in mules-n. Ir Ell-:I'lpartsfamtml mmitwr'lwitam Flaltflnd we:le cells (En) i'ne Enamel linen. Tm Isms nl all-mill lmlsele eels make my me tlllllea mellla. Bern-lean fl'le ermruhlm and samzdll meme is a plsmirm laser cl stash: limue. [he illlel elastic Emma tan-laws] Ihe nulermuel am of lllallessel mlsls malnlg- as mums [Issue lGT] Lmflmtesfi me MS as also seen. seen”. {El Elam-liar. ME 3. Hahlrnev: Hatters Ementlafl l-lisjzlaleluglslr 4 www.mdmtmnwlmnm '1 Lil of ma stoma aired pull). Lille lhe slrarna al other lymphaid organs. me spleen's strema consists of an extensive rename uf relieular liners [RH lar internal supper-r In rerl map, may aeaammadale many lymphocytes. mampnages. EI'IIEI [fliEl' sells in splenie auras They alsa aunpart Ill$ sinusuias. A 'l’él'iElUS sinusnilj {V5, ail-aural is seen in longitudinal seslian. with silver stains. reilsalar liters ale blank llamas straan mat farm an intanuaauinu network in me argan. ESIZI x. name. 1" Hima- puwer Ll'.'l of red Fulfil. Uenaus sinuseids N5}. sea“- in transuarae and lanwminai lanawai mews. farm a tra‘liuaus. anastarmsing wassiiar remark. Each sinusoid has a I.i-lele lumen anrl ls lined nil seminal enaalhefial cells. Mscmphages elesely associated Iailn sinusoid walls niten requ're saeeiai technitpes for detectim Splenii: cards 151:] are in intervening areas af red pulp. 50th:. ear 1. El! [11‘ a splanie card. ‘il'an'nus elaser padied cells. imluai ng lymphocytes {Ly}. make up salenie earns. Fieiiwlar calls {as}. which are mdifiea liaratllasts. araelaca reticular fibers {HF} at tile strnma. EDDflsr. Ell Elseuier. (Nelle El lilahirneu: Platters Essential Hi:=.l:l:ili:ig-.ir — www.5tudentmnsult.:em ...
View Full Document

Page1 / 9

Lecture 9b - «I Llil ot' a lymphoid nodule in the paletlne...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online