1NetCmplxIntro

1NetCmplxIntro - Universals and fundamentals Network...

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Universals and fundamentals • Network architecture? Complexity? Robustness? ots of appealing ideas few fundamentals • Lots of appealing ideas, few fundamentals • Can we change this? heory: Fundamental laws constraints tradeoffs • Theory: Fundamental laws, constraints, tradeoffs • Illustrate with “simple” and familiar case studies henever possible whenever possible • Expand our thinking outside networking John Doyle John G Braun Professor Control and Dynamical System, Electrical Engineering, BioEngineering Caltech
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In the real (vs virtual) world What matters: What doesn’t: • Action • Data • Information • Computation earning • Learning • Decision •…
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Multiscale hysics My interests Physics Core theory Systems Network Centric, ervasive challenges Biology & Medicine Pervasive, Embedded, Ubiquitous Sustainability?
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Human complexity? Robustness? Fragility? Core theory Systems challenges Biology & Medicine
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Human complexity Robust Fragile Metabolism besity, diabetes Regeneration & repair Healing wound /infect Obesity, diabetes Cancer AutoImmune/Inflame
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Mechanism? Robust Fragile Metabolism besity, diabetes Regeneration & repair Healing wound /infect Obesity, diabetes Cancer AutoImmune/Inflame Fat accumulation Insulin resistance Fat accumulation Insulin resistance Proliferation Inflammation Proliferation Inflammation
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What’s the difference? Robust Fragile Metabolism besity, diabetes Regeneration & repair Healing wound /infect Obesity, diabetes Cancer AutoImmune/Inflame Fat accumulation Insulin resistance Proliferation Inflammation luctuating tatic Fluctuating energy Static energy Accident or necessity?
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What’s the difference? Robust Fragile Metabolism Obesity, diabetes Regeneration & repair Healing wound /infect Cancer AutoImmune/Inflame Fat accumulation Insulin resistance roliferation Proliferation Inflammation ontrolled ncontrolled Controlled Dynamic Uncontrolled Chronic Low mean High variability High mean Low variability
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Restoring robustness obust ragile Robust Fragile Controlled Dynamic Uncontrolled Chronic Low mean High variability High mean Low variability
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Mechanism? Robust Metabolism Regeneration & repair Healing wound /infect Fat accumulation Insulin resistance Proliferation Inflammation luctuating Controlled Fluctuating energy Dynamic Low mean High variability
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rain fast slow i h dynamics Brain eart I high Control? Heart GI Oxy ac/ph rity Glu Triglyc Lac/ph prio r Muscle lyc FFA Out w • Energy flammation Liver Glyc Glyc Glycerol low • Inflammation • Coagulation Evolved for large Fat energy variation and moderate trauma
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Human complexity Robust Yet Fragile etabolism besity diabetes Metabolism Regeneration & repair icrobe ymbionts Obesity, diabetes Cancer arasites infection Microbe symbionts Immune/inflammation euro- ndocrine Parasites, infection
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1NetCmplxIntro - Universals and fundamentals Network...

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