Cancer can run in families

Cancer can run in families - thatruninfamilies closerto...

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Cancer can run in families. The fact that multiple genetic changes are required to produce a cancer cell helps explain the  predispositions to cancer that run in families. An individual inheriting an oncogene or a mutant allele of a tumor-suppressor gene is one step  closer to accumulating the necessary mutations for cancer to develop. Geneticists are devoting much effort to finding inherited cancer alleles so that a predisposition  to certain cancers can be detected early in life. About 15% of colorectal cancers involve inherited mutations. o Many of these mutations affect the tumor-suppressor gene  adenomatous polyposis coli , or  APC . Normal functions of the  APC  gene include regulation of cell migration and adhesion. Even in patients with no family history of the disease,  APC  is mutated in about 60% of  colorectal cancers.
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