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Unformatted text preview: - older cells have shorter telomeres o telomere- repeated TTAGGG sequence o portion of telomere cap lost w/ each replication o cancer cells avoid telomeric shortening o adding to telomeric caps increased number of times cells could perform DNA replication wear-and-tear hypothesis- cells wear out, get damaged through age o damage over time limits cells ability to work properly o free radicals - atomic fragments containing an unpaired electron, produced by oxidative metabolism, can damage cells o glycation- process that causes glucose to link to proteins, reducing flexibility gene clock hypothesis- people over 100 years of age more likely to have mutated C150T mitochondrial DNA o Werners syndrome - causes premature aging, found on chromosome 8, affects helicase enzyme in DNA repair current aging theories- still no true mechanism for counting o connection found between aging, signaling from insulin-like receptors...
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This note was uploaded on 01/04/2012 for the course BSC BSC1005 taught by Professor Orlando,rebecca during the Fall '10 term at Broward College.
- Fall '10