Unformatted text preview: Binding of ligands to receptors triggers the formation of a vesicle by the coated pit, bringing the bound substances into the cell. Receptor-mediated endocytosis enables a cell to acquire bulk quantities of specific materials that may be in low concentrations in the environment. Human cells use this process to take in cholesterol for use in the synthesis of membranes and as a precursor for the synthesis of steroids. Cholesterol travels in the blood in low-density lipoproteins (LDL), complexes of protein and lipid. These lipoproteins act as ligands to bind to LDL receptors and enter the cell by endocytosis. In an inherited disease called familial hypercholesterolemia, the LDL receptors are defective, leading to an accumulation of LDL and cholesterol in the blood. This contributes to early atherosclerosis....
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- Fall '10
- Biology, Atherosclerosis, Adenosine triphosphate, Familial hypercholesterolemia