Chapter 13 DNA Structure and Function

Chapter 13 DNA Structure and Function - Chapter 13 DNA...

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Chapter 13 DNA Structure and Function I. Cardboard Atoms and Bent-Wire Bonds A. Linus Pauling discovered the helical structure of proteins in 1951. B. In 1953, Watson and Crick discovered the structure of the master molecule of life —DNA. II. Discovery of DNA Function A. In 1868, Miescher first isolated deoxyribonucleic acid, or DNA, from cells in pus and from fish sperm. No one knew its function. B. A Puzzling Transformation 1. In 1928, Fred Griffith was working with S (virulent) and R (nonvirulent) strains of a pneumonia-causing bacterium. 2. He performed four experiments summarized here. a. Inject mice with R cells; mice lived. b. Inject mice with S cells; mice died; blood samples contained many S cells. c. S cells were killed then injected into mice; mice lived. d. Live R cells plus heat-killed S cells were injected into mice; mice died; live S cells were found in the blood. 3. Some substance from the S cells had transformed the R cells. a. Both proteins and nucleic acids were candidates. b. Oswald Avery showed that the substance was DNA.
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Chapter 13 DNA Structure and Function - Chapter 13 DNA...

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