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Checkpoints - Checkpoints Cancer checkpoint specific points...

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Checkpoints, Cancer checkpoint - specific points where cell cycle can be put on hold 2 irreversible points - replication of genetic material, sister chromatid separation kinase - adds phosphate phosphatase - takes away phosphate phosphorylation/dephosphorylation >> activate/deactivate proteins >> drives cell cycle cyclin - proteins displaying characteristic patterns of synthesis/degradation like the cell cycle cyclin-dependent kinase (Cdk) - enzyme that controls passage through the checkpoints multicellular organisms respond to more external signals and use more Cdk’s than unicellular organisms G1/S checkpoint - main point where the cell decides whether or not to divide links cell division to cell growth aka “restriction point” (R point) in animals aka “start” in yeasts decision to replicate genome >> decision to replicate internal signals - nutritional cell state, cell size external signals - factors that promote cell growth/division G2/M checkpoint
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