Chromatin modifications affect the availability of genes for transcription

Chromatin modifications affect the availability of genes for transcription

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Chromatin modifications affect the availability of genes for transcription. The DNA of eukaryotic cells is packaged with proteins in a complex called chromatin. The location of a gene’s promoter relative to nucleosomes and to the sites where the DNA  attaches to the chromosome scaffold or nuclear lamina can affect whether the gene is transcribed. Genes of densely condensed heterochromatin are usually not expressed, presumably because  transcription proteins cannot reach the DNA. A gene’s location relative to nucleosomes and to attachment sites to the chromosome scaffold  or nuclear lamina can affect transcription. Histone modifications regulate gene transcription. Chemical modifications of the histones and DNA of chromatin play a key role in chromatin  structure and gene expression.
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This note was uploaded on 01/04/2012 for the course BSC BSC1005 taught by Professor Orlando,rebecca during the Fall '10 term at Broward College.

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Chromatin modifications affect the availability of genes for transcription

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