Concept 27 -...

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Concept 11.2 Reception: A signal molecule binds to a receptor protein, causing it to change  shape. The cell targeted by a particular chemical signal has a receptor protein on or in the target cell  that recognizes the signal molecule. Recognition occurs when the signal binds to a specific site on the receptor that is  complementary in shape to the signal. The signal molecule behaves as a  ligand,  a small molecule that binds with specificity to a  larger molecule. Ligand binding generally causes the receptor protein to undergo a change in shape. Ligand binding may activate the receptor so that it can interact with other molecules. o For other receptors, ligand binding causes aggregation of receptor molecules, leading to  further molecular events inside the cell. In a general sense, ligand binding is similar to the binding of an allosteric regulator to an  enzyme, causing a shape change that either promotes or inhibits enzyme activity. In the case of signal transduction, binding of the ligand alters the ability of the receptor to  transmit the signal.
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This note was uploaded on 01/04/2012 for the course BSC BSC1005 taught by Professor Orlando,rebecca during the Fall '10 term at Broward College.

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Concept 27 -...

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