Concept22 - Concept 6.5 Regulation of enzyme activity helps...

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Unformatted text preview: Concept 6.5 Regulation of enzyme activity helps control metabolism Metabolic control often depends on allosteric regulation. In many cases, the molecules that naturally regulate enzyme activity behave like reversible noncompetitive inhibitors. Regulatory molecules often bind weakly to an allosteric site, a specific receptor on the enzyme away from the active site. Binding by these molecules can either inhibit or stimulate enzyme activity. Most allosterically regulated enzymes are constructed of two or more polypeptide chains. Each subunit has its own active site. Allosteric sites are often located where subunits join. The binding of an activator stabilizes the conformation that has functional active sites, while the binding of an inhibitor stabilizes the inactive form of the enzyme. As the chemical conditions in the cell shift, the pattern of allosteric regulation may shift as...
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