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Unformatted text preview: Mutations to tumor-suppressor genes may contribute to cancer. The normal products of tumor-suppressor genes inhibit cell division. Any decrease in the normal activity of a tumor-suppressor protein may contribute to cancer. Some tumor-suppressor proteins normally repair damaged DNA, preventing the accumulation of cancer-causing mutations. Other tumor-suppressor proteins control the adhesion of cells to each other or to an extracellular matrix, which is crucial for normal tissues and often absent in cancers. Still others are components of cell-signaling pathways that inhibit the cell cycle. Oncogene proteins and faulty tumor-suppressor proteins interfere with normal cell-signaling pathways. The proteins encoded by many proto-oncogenes and tumor-suppressor genes are components of cell-signaling pathways....
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