Scaffolding proteins and signaling complexes contribute to signaling efficiency

Scaffolding proteins and signaling complexes contribute to signaling efficiency

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Scaffolding proteins and signaling complexes contribute to signaling efficiency. Rather than relying on the diffusion of large relay molecules such as proteins, many signal  pathways are linked together physically by  scaffolding proteins . __________ Scaffolding proteins may themselves be large relay proteins to which several other  relay proteins attach. o For example, one scaffolding protein isolated from mouse brain cells holds three protein  kinases and carries these kinases with it when it binds to an appropriately activated membrane receptor, facilitating a  specific phosphorylation cascade. Some scaffolding proteins in brain cells  permanently  hold together networks of signaling- pathway proteins at synapses. o This hardwiring enhances the speed, accuracy, and efficiency of signal transfer between cells. When signaling pathways were first discovered, they were thought to be linear, independent 
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This note was uploaded on 01/04/2012 for the course BSC BSC1005 taught by Professor Orlando,rebecca during the Fall '10 term at Broward College.

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Scaffolding proteins and signaling complexes contribute to signaling efficiency

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