Sickle - Hemochromatosis Hemochromatosis is a disease that...

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Sickle-Cell Anemia Sickle-cell anemia is an abnormality of hemoglobin, the molecule that carries oxygen in our blood. Hemoglobin is contained within red blood cells. When the oxygen concentration in the hemoglobin molecules becomes low, the molecules stick together forming long rods that distort the cell (picture below). The cells break down or clog blood vessels causing pain, poor circulation, jaundice, anemia, internal hemorrhaging, low resistance, and damage to internal organs. Death usually occurs before age 50. Heterozygotes (carriers) are not affected with anemia and are resistant to malaria. Eight to ten percent of African Americans carry the allele (have sickle-cell trait).
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Unformatted text preview: Hemochromatosis Hemochromatosis is a disease that causes the body to absorb more iron from food than normal. High iron levels can lead to organ damage if it is left untreated for many years. Symptoms include joint pain, fatigue, and abdominal pain. There are two different mutations of the gene that causes hemochromatosis (the HFE gene) and the severity of symptoms depends on the mutations that are inherited. One in 200 people in the United States carry the gene and it is the most common genetic disease in people of northern European descent. There is also a form of this disease that is not due to genetic factors, it is acquired....
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