Transcriptional Control

Transcriptional Control - - changes mRNA produced by...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Transcriptional Control, DNA Motifs overview of transcriptional control - important for adaptation, development, homeostasis regulating promoter access - controls start of transcription o binding proteins to regulatory sequence blocks/catalyzes binding of RNA polymerase o promoter (nucleotide sequence) tells polymerase where to start transcribing transcriptional control in prokaryotes - prokaryotes grow/divide as quickly as possible o adjusts cell’s activities to immediate environment o reversible changes, lets cell adjust enzymes levels up/down transcriptional control in eukaryotes - eukaryotes protected from changes in immediate environment o regulates body as a whole, not just individual cells o controls growth/development o enzymes for a particular developmental change stops working after the change takes place posttranscriptional control
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: - changes mRNA produced by transcription DNA-binding motifs- proteins have special structure to bind to DNA on major groove major groove- contains hydrogen atoms, hydrogen bond donors/acceptors, hydrophobic methyl groups helix-turn-helix- most common motif o made up of 2 alpha-helical segments connected by nonhelical segment o recognition helix - fits into major groove of DNA molecule o more protein-DNA-binding sites increases strength of bond between them homeodomain motif- helix-turn-helix motfi in center zinc finger motif- uses zinc to coordinate binding to DNA o more zinc fingers in cluster >> stronger link between protein/DNA leucine zipper motif- 2 different protein subunits make a single binding site o Y-shape, allows for greater flexibility in gene control...
View Full Document

This note was uploaded on 01/04/2012 for the course BSC BSC1005 taught by Professor Orlando,rebecca during the Fall '10 term at Broward College.

Ask a homework question - tutors are online