Translation presents an opportunity for the regulation of gene expression

Translation presents an opportunity for the regulation of gene expression

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Unformatted text preview: Translation presents an opportunity for the regulation of gene expression. The initiation of translation of an mRNA can be blocked by regulatory proteins that bind to specific sequences or structures within the 5 UTR of the mRNA, preventing ribosome attachment. The mRNAs present in the eggs of many organisms lack poly-A tails of sufficient length to allow initiation of translation. During embryonic development, a cytoplasmic enzyme adds more adenine nucleotides so that translation can begin at the appropriate time. Translation of all the mRNAs in a eukaryotic cell may be regulated simultaneously by the activation or inactivation of the protein factors required to initiate translation. This mechanism starts the translation of mRNAs that are stored in eggs. Just after fertilization, translation is triggered by the sudden activation of translation initiation...
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