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Unformatted text preview: The incidence is in 1,500 newborn males. Most (75%) have hemophilia A, a lack of clotting factor VIII. Hemophilia B- "Christmas Disease" is a defect in clotting factor IX. Transfusions of fresh whole blood or plasma or factor concentrates control bleeding but have previously caused AIDS infections. The human gene has been isolated and cloned using recombinant DNA techniques. This is leading to improved treatment. Royal Families of Europe Victoria (granddaughter of George III) was a carrier and spread the gene to the royal families of Europe. Her granddaughter Alix- married Czar Nicholas II of Russia. The Czars son Alexis, heir to the throne, had hemophilia. The Czar's preoccupation with Alexis' health contributed to the revolution that overthrew the throne and eventually led to the communist government....
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- Fall '10