AP Biology (HW 16) (1)

AP Biology (HW 16) (1) - Homework #16 : Chapter 16 (due...

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Homework #16 : Chapter 16 (due Friday 111216 ) ONE Concept Map: 10 points The Molecular Basis of Inheritance Amit Patel P3 12/15/11 #19 Objectives DNA as the Genetic Material 1. Explain why researchers originally thought protein was the genetic material. T.H. Morgan’s group proved genes are located on chromosomes. Since there were only 2 components to chromosomes: proteins and nucleic acids, both became candidates for genetic material. Proteins were originally thought as genetic material, since they were macromolecules with great heterogeneity and specificity of function, essential requirements for the hereditary material. -genes located chromosomes -DNA & protein components chromosomes - candidates genetic material -proteins macromolecules -functions ofhereditary material 2. Summarize the experiments performed by the following scientists that provided evidence that DNA is the genetic material: a. Frederick Griffith b. Oswald Avery, Maclyn McCarty, and Colin MacLeod c. Alfred Hershey and Martha Chase d. Erwin Chargaff Griffith discovered transformation, a change in genotype and phenotype due to assimilation of external DNA by a cell while performing experiments on bacteria. Avery, McCarty, and MacLeod discovered that DNA acted as the transforming agent, and finally Hershey and Chase experimented and proved that nucleic acid are the hereditary material of life. Chargaff discovered the four nitrogenous bases and established rules about them that made their specific pairing very apparent. -transformation (Griffith) -transforming agent was DNA (Avery/McCarty) -nucleic acids are hereditary material (Hershey/Chase) -4 nitrogenous bases rules (Chargaff)
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3. Explain how Watson and Crick deduced the structure of DNA and describe the evidence they used. Explain the significance of the research of Rosalind Franklin. When Watson and Crick viewed Franklin’s X ray crystallography picture of DNA, they were, based on the placement and distance of the nitrogen base pairs, able to deduce that DNA was a double helix molecule. The structure of DNA was a double helix. -protein structure -X-ray crystallography -X-ray diffraction -photograph of DNA -used Franklin’s -DNA was double helix 4. Describe the structure of DNA. Explain the base-pairing rule and describe its significance. DNA is a double helix, formed by two adjacent polynucleotide strands wound into a
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AP Biology (HW 16) (1) - Homework #16 : Chapter 16 (due...

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