Lecture%203-4%20Microfluidics%2C%20Reynolds%2C%20Time%20scales%2C%20and%20Bulk%20Micromachining

Lecture%203-4%20Microfluidics%2C%20Reynolds%2C%20Time%20scales%2C%20and%20Bulk%20Micromachining

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
tro BioMEMS and Nanobiotech Intro BioMEMS and Nanobiotech - Microfluidics -Bulk Micromaching -Silicon Crystallography T. K. Hsiai, MD, PhD, FACC
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Scaling and the design of miniaturized chemical-analysis systems Nature 442 , 374-380 (27 July 2006) | doi:10.1038/nature05059; Published online 26 July 2006 Dirk Janasek, Joachim Franzke and Andreas Manz Motivation -microfluidics, micrometre-scale total analysis systems ( TAS) or so-called 'lab-on-a-chip' devices -important principles that contribute to the design of novel TAS and to propose future research activity -even before starting an experiment, we can establish whether or not the device will function The figure compares the size of a commercial gas chromatograph and column with that of a microscaled column on a chip. (Photo of microscaled column courtesy of J. Müller, Institut für Mikrosystemtechnik, Technische Universität Hamburg-Harburg, Germany.)
Background image of page 2
icrofluidics pplications Microfluidics-Applications Microfluidic devices are an important new tool for use in the study of dynamics of biologically significant molecules. For example, microfluidic mixers can initiate a chemical or biological process gp in microseconds and allow the dynamics to be monitored over many orders of magnitude in time – om microseconds to seconds and longer from microseconds to seconds and longer. In the micron-sized channels, the fluid flow is mpletely laminar and fast mixing is achieved by completely laminar, and fast mixing is achieved by hydrodynamic focusing.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
icrofluidics ased lab n hip Microfluidics -based lab-on-a-chip www.devicelink.com/ivdt/archive/00/11/008.html
Background image of page 4
Conventional genetic analysis protocols have several unit operations in common. The most common of these is the need to measure, mix, d transport and position liquid samples. For integrated and transport and position liquid samples. For integrated microsytems, these steps demand the need for efficient components for metering, mixing and transferring nanoliter zed or smaller liquid samples in a microfabricated -sized or smaller liquid samples in a microfabricated analysis device.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Steps to Constructing Microfluidic Devices We construct devices using soft lithography techniques. The micron-sized channels are molded in a plastic called PDMS (poly-dimethylsiloxane) and bonded to a icroscope slide. Because this material is transparent over a broad spectral range, microscope slide. Because this material is transparent over a broad spectral range, (from infrared to ultraviolet) we can use these devices to perform many different types of spectroscopic studies on biological systems.
Background image of page 6
Applications Lab-on-a-Chip and Biological Assaying -Dielectrophoresis, electrowetting on dielectric, electrophoresis, electroosmosis, ule heating, electro- ray ionization joule heating, electro spray ionization -Sample injection, mixing, chemical reaction, separation, and detection -Capillary filling, pin spotting, surface wetting icrofluidic pumps valves and channel flows -Microfluidic pumps, valves, and channel flows -Biological cell motion and deformation
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 68

Lecture%203-4%20Microfluidics%2C%20Reynolds%2C%20Time%20scales%2C%20and%20Bulk%20Micromachining

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online