11_outline_MetDiv

11_outline_MetDiv - Metabolism Lectures Outline Part I...

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Metabolism Lectures Outline: Part I: Fermentations Part II: Respiration Part III: Metabolic Diversity Learning objectives are : Learn about anaerobic respiratory metabolisms. How can an inorganic compound be use as an energy source.
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Respiration Review 2NADH Q 2NAD+ 2H+ 2H+ H+ H+ O 2 4H+ 2 H 2 O H+ H+ per cyto low E o electron flow hi E o ATP ADP 3H+ Electron Tower
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Anaerobic Respiration Anaerobic metabolism is of clinical importance: Deep tissue infections can lead to abscess formation, foul- smelling pus, and tissue destruction Uses inorganic and organic molecules other than oxygen as terminal electron acceptors Extensive list of electron acceptors oxyanions, metals, metal oxides, organic acids, inorganic Energy and carbon sources are diverse
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Metabolic Classification Based on Oxygen Concentrations Points of reference: Atmospheric oxygen is ~21% (v/v) (or 2.1 x 10 5 parts per million) Low solubility in water: up to 14 parts per million (T and P dependent) Remember metabolic classifications: Strict aerobe (non-fermentative, respires oxygen) Strict anaerobe (sensitive to oxygen) Facultative anaerobe: (fermentative and/or respiration) Microaerophilic (or microaerophile) 40:1 anaerobes to facultative anaerobes in human feces
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Diversity of electron acceptors for respiration Organic compounds : Eg. fumarate, dimethylsulfoxide (DMSO), Trimethylamine-N- oxide (TMAO) Inorganic compounds : Eg. NO 3 - , NO 2 - , SO 4 2- , S 0 , SeO 4 2- , AsO 4 3- Metals : Eg. Fe 3+ , Mn
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