Lec 12 Cell Comunications PDF (I) 1-6

Lec 12 Cell Comunications PDF (I) 1-6 - Biol 113 AU2011...

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1 Biol 113 AU2011 Lecture 12 Cell-Cell Communications (I) A. Overview: The cellular internet B. Evolution of cell signaling C. Local and long-distance signaling D. The three stages of cell signaling: A preview E. Reception: A signal molecule binds to a receptor protein, causing it to change shape A. Overview: The Cellular Internet Cell-to-cell communication is essential for multicellular organisms Biologists have discovered some universal mechanisms of cellular regulation The combined effects of multiple signals determine cell response For example, the dilation of blood vessels is controlled by multiple molecules B. Evolution of Cell Signaling A signal transduction pathway is a series of steps by which a signal on a cell’s surface is converted into a specific cellular response Signal transduction pathways convert signals on a cell’s surface into cellular responses Microbes are a window on the role of cell signaling in the evolution of life Fig. 11-2 Receptor α factor a factor a α α a Exchange of mating factors Yeast cell, mating type a Yeast cell, mating type α Mating New a/ α cell a/ α 1 2 3 Fig. 11-3 Individual rod- shaped cells
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Lec 12 Cell Comunications PDF (I) 1-6 - Biol 113 AU2011...

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