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Unformatted text preview: Build up of Amyloid in Alzheimer’s Disease (arrow)
Build Amyloid (red) in non-immunized
mouse (top) is removed in mice
after immunization (bottom) Removal of brain amyloid in an AD
patient following active immunization (top)
Persistence of brain amyloid in a nonimmunized patient (bottom) Amyloid Fibril Nerve Cell Medications may promote removal of amyloid by interfering
with clumping of amyloid fibrils New medications may prevent deposits of amyloid by
modulating specific enzymes
modulating β -amyloid precursor protein
space TM Cytoplasm Aβ peptide
COOH NH2 β -secretase Abeta-42
Selkoe DJ et al. JAMA. 2000;283:1615-1617. alpha-secretase Abeta-40 γ -secretase Abeta-42 ...
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This note was uploaded on 01/06/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.
- Fall '11