Amyloid-1 - Build up of Amyloid in Alzheimer’s Disease...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Build up of Amyloid in Alzheimer’s Disease (arrow) Build Amyloid (red) in non-immunized mouse (top) is removed in mice after immunization (bottom) Removal of brain amyloid in an AD patient following active immunization (top) Persistence of brain amyloid in a nonimmunized patient (bottom) Amyloid Fibril Nerve Cell Medications may promote removal of amyloid by interfering with clumping of amyloid fibrils New medications may prevent deposits of amyloid by modulating specific enzymes modulating β -amyloid precursor protein Extracellular space TM Cytoplasm Aβ peptide COOH NH2 β -secretase Abeta-42 Selkoe DJ et al. JAMA. 2000;283:1615-1617. alpha-secretase Abeta-40 γ -secretase Abeta-42 ...
View Full Document

This note was uploaded on 01/06/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

Ask a homework question - tutors are online