amyloid - Amphotericin B Two-edged sword or Swiss army...

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Amphotericin B Two-edged sword or Swiss army knife? Bridging the gap between Alzheimer’s and Prion diseases.
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What are some Amyloid Diseases? Alzheimer’s disease Atrial Amyloidosis Hereditary Renal Amyloidosis Secondary Systematic Amyloidosis Injection-Localized Amyloidosis
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What are some Prion Diseases? Chronic Wasting Disease (CWD) Scrapie BSE- Mad Cow Disease Kuru Creutzfeldt-Jakob Disease
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Amyloids vs Prions Prions are known to be infectious in their spreading to different hosts, e.g. CWD, BSE, kuru, etc… Amyloid diseases - not thought to be infectious agents but….
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Amyloids vs. Prions-news! It has been recently shown that mice who were fed amyloid fibrils (from the spleen of infected mice) orally (in H 2 O) developed amyloid deposits upon stimulation.
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Amyloids vs. Prions, pt. II Similar propagation of fibrils in vitro. Similar symptoms (inflammatory neuropathies) and adverse affects from having the disease.
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These diseases involve fibril deposits: What is a fibril? Normal PrP or A β protein may misfold into a beta sheet structure The beta sheets form extended aggregate fiber structures by “recruiting” properly folded proteins These fibrils are protease resistant and insoluble This is the most prevalent characteristic of amyloid and prion diseases.
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Alzheimer’s Disease Amyloid hypothesis
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Possible approaches to treating Amyloid and Prion Diseases. 1. Physical blockage of fibril growth (by small
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This note was uploaded on 01/06/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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amyloid - Amphotericin B Two-edged sword or Swiss army...

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