Friday.harb.Cancer

Friday.harb.Cancer - Cancer and Toxins in the Web An...

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Cancer & Toxins – 3/24/05 An Introduction To Toxicology and Cancer Cancer and Toxins in the Web Steven G. Gilbert, PhD, DABT www.asmalldoseof.org Friday Harbor, San Juan Island March 24, 2005
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Cancer & Toxins – 3/24/05 Quote / History " There is no treatment.“ 1600 B.C. Egypt (comment on breast cancer)
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Cancer & Toxins – 3/24/05 Incidence of Breast Cancer A Women’s Risk of Breast Cancer (US) 1940’s – 1 in 22 2004 – 1 in 7 WHY? Breast Cancer is leading cause of death in women ages 34 to 44.
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Cancer & Toxins – 3/24/05 Incidence of Breast Cancer A Women’s Risk of Breast Cancer (WA) ACS 148 per 100,000 WA cancer registry – 181 per 100,000 WHY? This year in WA 4,000 women diagnosed with BC 800 will die of BC Highest rate in US
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Cancer & Toxins – 3/24/05 The study of poisons or the adverse effects of chemical and physical agents on living organisms. Toxicology Definitions
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Cancer & Toxins – 3/24/05 “Conditions that ensure that all living things have the best opportunity to reach and maintain their full genetic potential.” Steven G. Gilbert, 1999 Environmental Health
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Cancer & Toxins – 3/24/05 Key Words Risk = Hazard X Exposure Dose / Response Individual Sensitivity
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Cancer & Toxins – 3/24/05 What Is This? N N N N CH 3 CH 3 CH 3 O O 1 3 7
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Cancer & Toxins – 3/24/05 Effects of Amount on Response
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Cancer & Toxins – 3/24/05 Effects of Size on Response
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Cancer & Toxins – 3/24/05 Case Studies Thalidomide Ethanol (Alcohol) Methylmercury Lead PBDEs
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Cancer & Toxins – 3/24/05 Thalidomide Introduced in 1956 as sedative (sleeping pill) and to reduce nausea and vomiting during pregnancy Withdrawn in 1961 Discovered to be a human teratogen causing absence of limbs or limb malformations in newborns 5000 to 7000 infants effected Resulted in new drug testing rules
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Cancer & Toxins – 3/24/05 What Is This? C H H H OH C H H (CH 3 -CH 2 -OH)
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Cancer & Toxins – 3/24/05 FAS Child
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Cancer & Toxins – 3/24/05 Lead In Homes
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Cancer & Toxins – 3/24/05 40 30 25 20 15 10 0 5 10 15 20 25 30 35 40 Blood Lead (ug/dl) CDC 1973 1975 1985 WHO 1986 EPA 1990 Agency and Year Acceptable Childhood Blood Lead Levels CDC Blood Lead Levels
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Cancer & Toxins – 3/24/05 The Mercury Cycle
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Cancer & Toxins – 3/24/05 Structure of PBDEs X & Y are number of Bromine atoms Common Penta, Octa, and Deca PolyBrominated Diphenyl Ether O Br x Br y
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Cancer & Toxins – 3/24/05 PBDEs in House Dust (ppb) From EWG - Toxic Fire Retardants Contaminate American Homes - http://www.ewg.org/reports/inthedust/summary.php
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Cancer & Toxins – 3/24/05 PBDEs in Breast Milk (ppb) From EWG - Toxic Fire Retardants in Breast Milk from American Mothers - http://www.ewg.org/reports/mothersmilk/es.php
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Cancer & Toxins – 3/24/05 Ancient Awareness 80 Million years ago – Dinosaur bones show evidence of cancer 3000 BC - Egyptian mummies – bone cancer 1600 BC – Egypt – 8 cases of breast tumors (or ulcers) Treated by cauterization – with the “fire drill” - Edwin Smith Papyrus
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Cancer & Toxins – 3/24/05 Ancient Awareness 300 BC – Hippocrates named tumors as carcinos or carcinoma – tumors spread out like legs of a crab 1500 – autopsy start to provide a greater understanding of cancer 1650 – more knowledge with advance in medical science tools like the microscope
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This note was uploaded on 01/06/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Friday.harb.Cancer - Cancer and Toxins in the Web An...

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