{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Friday.harb.Cancer - Cancer and Toxins in the Web An...

Info icon This preview shows pages 1–23. Sign up to view the full content.

View Full Document Right Arrow Icon
Cancer & Toxins – 3/24/05 An Introduction To Toxicology and Cancer Cancer and Toxins in the Web Steven G. Gilbert, PhD, DABT www.asmalldoseof.org Friday Harbor, San Juan Island March 24, 2005
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cancer & Toxins – 3/24/05 Quote / History " There is no treatment.“ 1600 B.C. Egypt (comment on breast cancer)
Image of page 2
Cancer & Toxins – 3/24/05 Incidence of Breast Cancer A Women’s Risk of Breast Cancer (US) 1940’s – 1 in 22 2004 – 1 in 7 WHY? Breast Cancer is leading cause of death in women ages 34 to 44.
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cancer & Toxins – 3/24/05 Incidence of Breast Cancer A Women’s Risk of Breast Cancer (WA) ACS 148 per 100,000 WA cancer registry – 181 per 100,000 WHY? This year in WA 4,000 women diagnosed with BC 800 will die of BC Highest rate in US
Image of page 4
Cancer & Toxins – 3/24/05 The study of poisons or the adverse effects of chemical and physical agents on living organisms. Toxicology Definitions
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cancer & Toxins – 3/24/05 “Conditions that ensure that all living things have the best opportunity to reach and maintain their full genetic potential.” Steven G. Gilbert, 1999 Environmental Health
Image of page 6
Cancer & Toxins – 3/24/05 Key Words Risk = Hazard X Exposure Dose / Response Individual Sensitivity
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cancer & Toxins – 3/24/05 What Is This? N N N N CH 3 CH 3 CH 3 O O 1 3 7
Image of page 8
Cancer & Toxins – 3/24/05 Effects of Amount on Response
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cancer & Toxins – 3/24/05 Effects of Size on Response
Image of page 10
Cancer & Toxins – 3/24/05 Case Studies Thalidomide Ethanol (Alcohol) Methylmercury Lead PBDEs
Image of page 11

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cancer & Toxins – 3/24/05 Thalidomide Introduced in 1956 as sedative (sleeping pill) and to reduce nausea and vomiting during pregnancy Withdrawn in 1961 Discovered to be a human teratogen causing absence of limbs or limb malformations in newborns 5000 to 7000 infants effected Resulted in new drug testing rules
Image of page 12
Cancer & Toxins – 3/24/05 What Is This? C H H H OH C H H (CH 3 -CH 2 -OH)
Image of page 13

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cancer & Toxins – 3/24/05 FAS Child
Image of page 14
Cancer & Toxins – 3/24/05 Lead In Homes
Image of page 15

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cancer & Toxins – 3/24/05 40 30 25 20 15 10 0 5 10 15 20 25 30 35 40 Blood Lead (ug/dl) CDC 1973 CDC 1975 CDC 1985 WHO 1986 EPA 1986 CDC 1990 Agency and Year Acceptable Childhood Blood Lead Levels CDC Blood Lead Levels
Image of page 16
Cancer & Toxins – 3/24/05 The Mercury Cycle
Image of page 17

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cancer & Toxins – 3/24/05 Structure of PBDEs X & Y are number of Bromine atoms Common Penta, Octa, and Deca PolyBrominated Diphenyl Ether O Br x Br y
Image of page 18
Cancer & Toxins – 3/24/05 PBDEs in House Dust (ppb) From EWG - Toxic Fire Retardants Contaminate American Homes - http://www.ewg.org/reports/inthedust/summary.php
Image of page 19

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cancer & Toxins – 3/24/05 PBDEs in Breast Milk (ppb) From EWG - Toxic Fire Retardants in Breast Milk from American Mothers - http://www.ewg.org/reports/mothersmilk/es.php
Image of page 20
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern