SampleChemPaperReview - T h is m a n u s c rip t is a w e...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This manuscript is a well written and generally interesting approach to minimizing sample volumes for single-molecule measurements. Publication requires attention to several issues. 1. The authors state in the abstract that channel diameters are created that match the confocal volume dimensions. Although it is true that some structures are made with dimensions similar to the confocal dimensions, the channels that are actually used for single-molecule analyses are considerably larger. The wording should be changed to avoid misinterpretation. In addition, the authors should discuss (in the Results section) why they did not use the smaller channels in single molecule measurements. 2. The introduction points out some of the shortfalls of other nanochannel approaches, including the fact that capillary nanochannels cannot support interconnection of nanofluidic elements. This, too, seems to be a limitation of the current method (all nanochannels must be parallel). In
Image of page 1
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern