SampleChemPaperReview - T h is m a n u s c rip t is a w e...

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This manuscript is a well written and generally interesting approach to minimizing sample volumes for single-molecule measurements. Publication requires attention to several issues. 1. The authors state in the abstract that channel diameters are created that match the confocal volume dimensions. Although it is true that some structures are made with dimensions similar to the confocal dimensions, the channels that are actually used for single-molecule analyses are considerably larger. The wording should be changed to avoid misinterpretation. In addition, the authors should discuss (in the Results section) why they did not use the smaller channels in single molecule measurements. 2. The introduction points out some of the shortfalls of other nanochannel approaches, including the fact that capillary nanochannels cannot support interconnection of nanofluidic elements. This, too, seems to be a limitation of the current method (all nanochannels must be parallel). In
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This note was uploaded on 01/06/2012 for the course UGS 303 taught by Professor Foster during the Fall '08 term at University of Texas.

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