SampleResponse2 - Dear Professor, We want to thank the...

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1 Dear Professor, We want to thank the referees of our manuscript, “XXXXX” for their assistance in the review process. Based on their comments, we have made several modifications, as itemized below. Reviewer I Reviewer I had several questions which were posed as a guide and did not specifically request answers to all points of discussion in this initial report. The reviewer asked, “What factors control the reproducibility of the pore size and shape? How do these features depend on material composition, laser stability, and membrane positioning? Can the pore be shaped for directing the delivery of chemical agents? Do the figures of merit that are given in the article refer to day-to-day reproducibility on different membranes, or to one study on one membrane, or to something else?” In this introductory work, we only examined two different membrane types: 6- µ m thick polycarbonate and 2.5- µ m thick Mylar. As discussed, smaller pores could be created in the Mylar. However, more systematic studies will be required to determine the individual contributions of material composition and membrane thickness to pore size. A statement to this effect has been added to the manuscript (page 14, 2 nd line of Conclusions): Although larger pores are created in polycarbonate membranes than in Mylar, more systematic studies will be required to determine the individual contributions of material composition and membrane thickness to pore size. As for the effect of laser stability on pore size, our findings indicate that a threshold laser power exists for ablation, and so long as the laser is set to a power comfortably above this level, the precise power setting does not appear to substantially alter pore size. Thus, the relatively small variability (~1% rms) in
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This note was uploaded on 01/06/2012 for the course UGS 303 taught by Professor Foster during the Fall '08 term at University of Texas.

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SampleResponse2 - Dear Professor, We want to thank the...

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