Hum_Mol_Genet_Lecture_6_February_28_2012

Hum_Mol_Genet_Lecture_6_February_28_2012 - Control of gene...

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Control of gene expression Transcriptional Post-transcriptional Epigenetics and long range control
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Control of gene expression Transcriptional Tissue specific transcription factors Binding of hormones, growth factors etc. to response elements Use of alternative promoters in a single gene
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Control of gene expression Post-transcriptional Alternative splicing Alternative polyadenylation Tissue specific RNA editing Translational control mechanisms
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Control of gene expression Epigenetics and chromatin structure Allelic exclusion (rearrangements, imprinting, X inactivation) Long range control by chromatin structure (position effects Pax6 in aniridia) Cell position-dependent, short range signaling
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Control of gene expression rRNA synthesis Arrows indicate cleavage sites
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Control of gene expression Initiation of transcription (RNA pol I) Initiation of transcription (RNA pol II)
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Control of gene expression tRNA and 5s RNA promoter elements Initiation of transcription (RNA pol III)
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Control of gene expression Conserved locations of promoter elements in eukaryotes
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Control of gene expression Insulin gene promoter organization NRE negative regulatory element CRE cAMP response element
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Control of gene expression HS-40 alpha-globin regulatory site Tissue specific regulation (many sites)
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Control of gene expression Structural domains in transcription factors HTH HLH Zn Finger Alpha-helix
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Control of gene expression Binding of conserved motifs to double helix
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Control of gene expression Steroid receptors and response elements GR ER PR RAR TR VDR
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Control of gene expression Transcription regulation by glucocorticoids
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This note was uploaded on 01/06/2012 for the course BIOL 4753 taught by Professor Batzer,m during the Fall '08 term at LSU.

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Hum_Mol_Genet_Lecture_6_February_28_2012 - Control of gene...

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