Unformatted text preview: response Combination results in 3-D data providing both
quantitative and qualitative information. time One critical aspect of GC-MS and LCMS is the interface.
Both chromatographic approaches
have relatively large flows.
GC - 1 - 50 ml / min
LC - 0.1 - 5 ml / min
- 50-5000 ml/min as a gas
The mass spec requires a vacuum of
about 10-5 - 10-6 torr - gas phase. flow from chromatograph Simplest approach
would be to split
the flow. MS waste Only allow what
the MS can handle
to actually enter. This can result in only 1/1000
or less of the sample to enter
the MS - not good for trace work ...
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