27_Hyphenated-page1

27_Hyphenated-page1 - response Combination results in 3-D...

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Unformatted text preview: response Combination results in 3-D data providing both quantitative and qualitative information. time One critical aspect of GC-MS and LCMS is the interface. Both chromatographic approaches have relatively large flows. GC - 1 - 50 ml / min LC - 0.1 - 5 ml / min - 50-5000 ml/min as a gas The mass spec requires a vacuum of about 10-5 - 10-6 torr - gas phase. flow from chromatograph Simplest approach would be to split the flow. MS waste Only allow what the MS can handle to actually enter. This can result in only 1/1000 or less of the sample to enter the MS - not good for trace work ...
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