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25_GC-page6 - We need a way to measure our eluents as they...

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We need a way to measure our eluents as they evolve from the column. Virtually every method of directly or indirectly observing eluents as been looked at. We’ll cover some of the more common types. Each can be roughly classified based on Destructive vs. nondestructive General vs. some discrimination vs. very discriminating Let’s start by reviewing some general concepts such as detection limit and sensitivity. High sensitivity - possible selectivity Rapidly respond to concentration changes Large linear range Stable with respect to noise and drift Low sensitivity to variations in flow,
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