Outline Chapter 4 - Topic 4 Renal Transport Mechanisms NaCl...

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Unformatted text preview: Topic 4 Renal Transport Mechanisms: NaCl and H 2 O Reabsorption along the Nephron Basic Transport Mechanisms for Reabsorption 1. Passive Transport/Diffusion Diffusion • Movement in which direction? • Energy? • Movement of cations • Movement of anions • Movement of lipid-soluble substances Osmosis • Definition - Driven by ____________________________________________ Solvent Drag • What is solvent drag? - Accounts for __________________________________________ Facilitated Diffusion Uniport • • 2. Active Processes • Carrier required? • Gradient: • Energy:- Direct: - Indirect: I. Coupled Transport A. Symport • • • B. Antiport • Na+-H+ antiporter in proximal tubule (apical membrane) mediates Na+ reabsorption and H+ secretion:-- This is an example of which type of secondary active transport? • Na+-K+ ATPase - Location in the nephron: • H+-ATPase • H+-K+ ATPase • Ca+ ATPase II. Endocytosis • Definition: • What is reabsorbed by this method? • Energy: General Principles of Transepithelial Solute and H 2 O Transport Reabsorption • Net transport of a substance from: - Secretion • Net transport of a substance from the:- Tight Junctions between Tubular Cells • A. Paracellular Pathway • Reabsorption or secretion of substances between cells • Example:- B. Transcellular pathway • Reabsorption or secretion of substances through cells. • Example:- Two-step process: a) b) NaCl and H 2 O Reabsorption Along the Nephron • Represents the major functions of nephrons. • How much of each reabsorbed?-- • Transport of many other (physiologically important) solutes directly/indirectly linked to Na+ reabsorption. I. Proximal Tubule 1. Na+ Reabsorption • • . • What is the key element in basolateral membrane of proximal tubule reabsorption? - First Half of Proximal Tubule • Na+ reabsorbed primarily with::- • Na+ uptake into the cell coupled with:-- • Entry into cell across apical membrane mediated by: Second Half of Proximal Tubule • Na+ reabsorbed primarily with:...
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Outline Chapter 4 - Topic 4 Renal Transport Mechanisms NaCl...

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