Outline Chapter 4 - Topic 4 Renal Transport Mechanisms:...

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Unformatted text preview: Topic 4 Renal Transport Mechanisms: NaCl and H 2 O Reabsorption along the Nephron Basic Transport Mechanisms for Reabsorption 1. Passive Transport/Diffusion Diffusion Movement in which direction? Energy? Movement of cations Movement of anions Movement of lipid-soluble substances Osmosis Definition - Driven by ____________________________________________ Solvent Drag What is solvent drag? - Accounts for __________________________________________ Facilitated Diffusion Uniport 2. Active Processes Carrier required? Gradient: Energy:- Direct: - Indirect: I. Coupled Transport A. Symport B. Antiport Na+-H+ antiporter in proximal tubule (apical membrane) mediates Na+ reabsorption and H+ secretion:-- This is an example of which type of secondary active transport? Na+-K+ ATPase - Location in the nephron: H+-ATPase H+-K+ ATPase Ca+ ATPase II. Endocytosis Definition: What is reabsorbed by this method? Energy: General Principles of Transepithelial Solute and H 2 O Transport Reabsorption Net transport of a substance from: - Secretion Net transport of a substance from the:- Tight Junctions between Tubular Cells A. Paracellular Pathway Reabsorption or secretion of substances between cells Example:- B. Transcellular pathway Reabsorption or secretion of substances through cells. Example:- Two-step process: a) b) NaCl and H 2 O Reabsorption Along the Nephron Represents the major functions of nephrons. How much of each reabsorbed?-- Transport of many other (physiologically important) solutes directly/indirectly linked to Na+ reabsorption. I. Proximal Tubule 1. Na+ Reabsorption . What is the key element in basolateral membrane of proximal tubule reabsorption? - First Half of Proximal Tubule Na+ reabsorbed primarily with::- Na+ uptake into the cell coupled with:-- Entry into cell across apical membrane mediated by: Second Half of Proximal Tubule Na+ reabsorbed primarily with:...
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This note was uploaded on 01/07/2012 for the course PHCH 6234 taught by Professor Farqui during the Winter '11 term at Palmer Chiropractic.

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Outline Chapter 4 - Topic 4 Renal Transport Mechanisms:...

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