PDF Working Copy Outline Chapter 6

PDF Working Copy Outline Chapter 6 - Chapter 6 Regulation...

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1 Chapter 6 Regulation of Effective Circulating Volume (ECV) and NaCl Balance What is the major solute of ECF? ________________ The amount of NaCl in ECF determines ECF osmolality determines the blood volume and blood pressure. Renal mechanisms involved in reabsorption of Na + (i.e., returning Na + to ECF after filtration), are critically important for: ____________________ ____________________ ____________________ Which organ is responsible for maintaining normal body Na + content? Na + excretion must exactly equal Na + intake. _____________________ To remain in Na + balance, a person who ingests 150 mEq of Na + daily must excrete how much of Na + daily? Changes in Na + balance do not normally alter ECF osmolality. Why? - Kidneys are major routes for excretion of NaCl from the body. - Play a major role in regulating the volume of ECF. - Normal conditions : Kidneys keep volume of ECF constant by doing what? - - … Ingestion > excretion ECF volume … Ingestion < excretion ECF volume - Body monitors volume of ECF and sends signals to kidneys … Make adjustments in NaCl excretion The Concept of Effective Circulating Volume (ECV) Is ECV measurable? Refers to the portion of ECF volume contained within the vascular system, and is “effectively” perfusing the tissues. Dependent on: - - - Normal individuals: - ECV varies directly with the:
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2 - A decrease in ECF and vascular volume, arterial pressure, or cardiac output (CO) is sensed by the body as a in ECV. - The opposite is true for an increase in ECF … ECF volume, vascular volume, arterial blood pressure (BP) and CO depend on: Kidneys alter NaCl excretion in response to ECV changes - ECV renal NaCl excretion … Restores ECV to normal Adequate tissue perfusion - ECV renal NaCl excretion (= Natriuresis ) restores ECV to normal set point Positive and Negative Na + Balance Mentioned before: Na + excretion exactly equals Na + intake … the process called? _____________ Positive Na + Balance - Extra Na + retained in the body, mostly in ECF - ECF volume expansion - - This increases blood volume and arterial pressure edema Negative Na + Balance - Excess Na + lost from the body - ECF volume contraction - - This decreases blood volume and arterial pressure In normal adults, changes in ECV parallel those of: ________________ ________________ ________________ Euvolemia - ECV is monitored by various sensors. Volume-Sensing System Effective Circulating Volume Sensors I. Vascular (most sensitive) A. Low pressure 1.
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3 B. High Pressure 1. 2. 3. II. Central Nervous System III. Hepatic Vascular Low-Pressure Volume Sensors Baroreceptors Respond to distension of these structures Location? Respond to “fullness” of vascular system
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This note was uploaded on 01/07/2012 for the course PHCH 6234 taught by Professor Farqui during the Winter '11 term at Palmer Chiropractic.

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PDF Working Copy Outline Chapter 6 - Chapter 6 Regulation...

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