1Chapter 6 Regulation of Effective Circulating Volume (ECV) and NaCl Balance •What is the major solute of ECF? ________________ •The amount of NaCl in ECF determines ECF osmolality →determines the blood volume and blood pressure. •Renal mechanisms involved in reabsorption of Na+(i.e., returning Na+to ECF after filtration), are critically important for: ____________________ ____________________ ____________________ •Which organ is responsible for maintaining normal body Na+content? •Na+excretion must exactly equal Na+intake. _____________________ •To remain in Na+balance, a person who ingests 150 mEq of Na+daily must excrete how much of Na+daily? •Changes in Na+balance do not normally alter ECF osmolality. Why?-•Kidneys are major routes for excretion of NaCl from the body. -Play a major role in regulating the volume of ECF. -Normal conditions: Kidneys keep volume of ECF constant by doing what? -… -… Ingestion > excretion →↑ECF volume … Ingestion < excretion →↓ECF volume -Body monitors volume of ECF and sends signals to kidneys … Make adjustments in NaCl excretion The Concept of Effective Circulating Volume (ECV) •Is ECV measurable? •Refers to the portion of ECF volume contained within the vascular system, and is “effectively” perfusing the tissues. •Dependent on: ---•Normal individuals: -ECV varies directly with the: … … …
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