Topic 8 Regulation of Acid-Base Balance •Acid-base balance is concerned with maintaining a normal H+ion concentration in the body fluids. •How is this balance achieved? -•Two mechanisms for buffering: --pH of Body Fluids •The H+ concentration of the body fluids is extremely low.-Arterial blood: 40 nEq/L (40 x 10-9) •Because of low concentration, H+concentration is expressed as the negative logarithm, or pH:pH = - log10[H+] •The normal H+ concentration of 40 x 10-9Eq/L is converted to pH as follows:pH = - log10[40 x 10-9Eq/L] = 7.4 •All cells, tissue, and organ processes are sensitive to pH. •Body fluid pH ranges from 6.8 to 7.8 -Life cannot exist outside of this range. •The normal range of arterial pH is 7.32 to 7.42Essential for all cellular functionsAlkalemia:Acidemia:•Three mechanisms contribute to maintaining pH in the normal range: 1. 2. 3.
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