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PDF Working Copy Outline Chapter 8

PDF Working Copy Outline Chapter 8 - Topic 8 Regulation of...

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Topic 8 Regulation of Acid-Base Balance Acid-base balance is concerned with maintaining a normal H + ion concentration in the body fluids. How is this balance achieved? - Two mechanisms for buffering: - - pH of Body Fluids The H+ concentration of the body fluids is extremely low. - Arterial blood: 40 nEq/L (40 x 10 -9 ) Because of low concentration, H + concentration is expressed as the negative logarithm, or pH: pH = - log 10 [H + ] The normal H+ concentration of 40 x 10 -9 Eq/L is converted to pH as follows: pH = - log 10 [40 x 10 -9 Eq/L] = 7.4 All cells, tissue, and organ processes are sensitive to pH. Body fluid pH ranges from 6.8 to 7.8 - Life cannot exist outside of this range. The normal range of arterial pH is 7.32 to 7.42 Essential for all cellular functions Alkalemia: Acidemia: Three mechanisms contribute to maintaining pH in the normal range: 1. 2. 3.
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