Working Copy Outline Chapter 5

Working Copy Outline Chapter 5 - Chapter 5 Regulation of...

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Unformatted text preview: Chapter 5 Regulation of Body Fluid Osmolality: Regulation of Water Balance Introduction Water constitutes ~ what % of a healthy adult human body? What are the two compartments of body water? - Are these two compartments in equilibrium? Water intake into the body by two methods: - - Excretion of H 2 0 or Water Loss: 1. Renal (tightly regulated) The organ responsible for: -regulating water balance and -is a major route for elimination of water? 2. Other Water loss from the body by other routes: 1. Insensible water loss 2. Sweat production 3. G.I. Tract -Water loss by 1, 2 & 3 cannot be regulated. Renal excretion of water is tightly regulated. Maintenance of water balance depends on precise matching of: -- If intake > losses : If intake < losses: Body fluid osmolality is maintained at what level? - Three Types of Urine Isoosmotic urine Hyperosmotic urine Hypoosmotic urine What would prompt kidneys to conserve water and produce a small volume of urine that is hyperosmotic with respect to plasma? - - Produce large volume of hypoosmotic urine? - Urine osmolality varies - corresponding urine volume can vary - Kidneys control water excretion independently of the excretion of other substances: --- Regulation of Body Fluid Osmolality Bodys Response to Water Deprivation (See handout and/or website) Person lost in the desert with no source of drinking water 1. Water continuously lost from the body in -- 2. Osmoreceptors in anterior hypothalamus stimulated -- 3. Receptor stimulation has two effects: -- 4. ADH blood kidneys 5. ADH causes water permeability of LDT and CD 6. H 2 O reabsorption H 2 O returned to body fluids -- _____________________________________________________________________ * When body fluid osmolality is increased or blood volume or pressure is reduced, the individual perceives thirst . Hypertonicity is more important. Bodys Response to Water Drinking (See handout and/or website) A person drinks water 1. Ingested H 2 O distributed throughout body fluids - 2. 3. Two effects of Inhibition of Osmoreceptors-- Also inhibits secretion of ADH from posterior pituitary 4. ADH in blood - water permeability of late DT and CD 5. water reabsorption by late DT and CD -- Corticopapillary Osmotic Gradient What is it? Osmolality of cortex is: - Is this similar to osmolality of other body fluids? - ISF osmolality progressively increases What solutes contribute to osmotic gradient, and what mechanisms deposit these solutes in ISF? The answer can be found in two processes: 1. Countercurrent multiplication 2. Urea recycling Countercurrent Multiplication (See handout for diagrams) Initial State No corticopapillary gradient shown Osmolality throughout Henles loop and in the surrounding ISF is________________....
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This note was uploaded on 01/07/2012 for the course PHCH 6234 taught by Professor Farqui during the Winter '11 term at Palmer Chiropractic.

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Working Copy Outline Chapter 5 - Chapter 5 Regulation of...

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