Degenerative Disc Disease 2 slide

Degenerative Disc Disease 2 slide - Lia M Nightingale Ph.D...

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11/10/2010 1 Lia M. Nightingale, Ph.D. Nucleus pulposus contains: Collagen (20% of dry weight) Elastin 90% water Proteoglycans (mostly aggrecan) Annulus fibrosus contains: Water Collagen (70% of dry weight) Proteoglycans (mostly aggrecan) Podichetty. 2007. Cell Mol Biol . 53:4.
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11/10/2010 2 a. Vitamin D b. Vitamin C c. Vitamin A d. Pantothenic acid a. Repeating disaccharide chain b. Protein core surrounded by repeating disaccharide chain c. Protein core surrounded by an oligosaccharide d. None of the above
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11/10/2010 3 Disc cell degradation exceeds synthesis Begins in teenage years Prevalence is unknown due to lack of standardized definition Has a genetic component Battie et al. 2006. J Bone Joint Surg . 88:3. Causes back pain one of the largest factors affecting the physical health status of elderly patients. Podichetty. 2007. Cell Mol Biol . 53:4.
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11/10/2010 4 Age/ Trauma ↓H 2 O in nucleus (90% → 70%) Increased compression stress
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Degenerative Disc Disease 2 slide - Lia M Nightingale Ph.D...

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